Evigrade

Beetroot juice / dietary nitrate (Beta vulgaris)

Food product rich in inorganic nitrate; sold as a sports supplement and a «biohack» BP-lowering aid; not registered as a medicine by AEMPS

ATC code: C09BX-BEETROOT(Beetroot / dietary nitrate (Beta vulgaris))

Brand names: Beet It Sport (James White), HumanN SuperBeets, Force Factor Total Beets

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

C

Athletic endurance

Not recommended

Beetroot juice is one of the most studied ergogenic supplements in sports science. The Jones 2018 review describes an average 1–3% improvement in time-to-exhaustion in recreational and sub-elite athletes after acute or short-term nitrate loading of 300–600 mg, 2–3 hours before exertion. In elite athletes with high baseline NO bioavailability the effect becomes negligible. Biohacker blogs promote beetroot as a «secret weapon for marathoners», yet the real gain is modest and unstable and is easily wiped out by poor sleep or feeding strategy. AESAN and AEMPS have not registered beetroot juice as an ergogenic aid. Pre-race chlorhexidine mouthwash abolishes the effect because antibacterial mouth care blocks the nitrate-to-nitrite step.

C

Mild arterial hypertension

Not recommended

Beetroot juice and powder are sold as a «natural way to lower blood pressure». The Siervo 2013 meta-analysis (n = 254, 16 trials) reported a reduction of about 4.4 mmHg systolic and 1.1 mmHg diastolic BP with 300–500 mg/day dietary nitrate. The Bahadoran 2017 update confirmed the modest effect and identified a nitrate-independent component. The effect is not significant in normotensive subjects. 2024 and SEH-LELHA 2022 do not include beetroot in hypertension treatment algorithms. Substituting ACE inhibitors, ARBs, thiazides or calcium channel blockers with beetroot juice is not justified. If BP remains above 140/90 mmHg, discuss standard pharmacotherapy with a general practitioner or cardiologist.

ICD-10: I10 · ICD-11: BA00.Z

D

“Cardiovascular wellness” (marketing claim)

Not recommended

Beetroot juice is sold as a «universal vascular remedy». Cardiovascular outcomes (myocardial infarction, stroke, mortality) are not demonstrated in quality RCTs: short-term gains in NO bioavailability do not translate into fewer cardiovascular events. 2017 re-evaluated nitrate safety and confirmed an acceptable daily intake of 3.7 mg/kg – a dietary, not therapeutic, threshold. 2021 builds primary prevention on , BP, lipid and glucose control and Mediterranean diet; beetroot fits as an ordinary vegetable, not a «drug». Regular dietary beetroot is safe and useful; high-dose nitrate powder supplements are marketing with disproportionately small benefit.

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Beetroot contains high inorganic nitrate (NO3−) concentrations. Enterosalivary recirculation converts part of the nitrate to nitrite (NO2−) via oral bacteria. In tissues with low oxygen partial pressure nitrite is reduced to nitric oxide (NO), a potent endogenous vasodilator. Increased NO bioavailability produces moderate vasodilation, lowered systemic vascular resistance and improved mitochondrial efficiency. The pathway is sensitive to antibacterial mouthwashes: chlorhexidine blocks the nitrate-to-nitrite step and neutralises the effect.

Safety

Contraindications

  • Combination with organic nitrates (nitroglycerin, isosorbide) – risk of severe hypotension
  • Combination with PDE-5 inhibitors (sildenafil, tadalafil, vardenafil)
  • History of oxalate kidney stones – beetroot is high in oxalates
  • Severe arterial hypotension
  • Hypersensitivity to beetroot

Serious adverse effects

  • Severe hypotension when combined with organic nitrates or PDE-5 inhibitors
  • Oxalate stone formation in predisposed patients
  • Methaemoglobinaemia in infants with excessive nitrate exposure

Common adverse effects

  • Pink or red urine and stool (beeturia) – harmless coloration by beetroot pigment
  • Abdominal discomfort, flatulence
  • Orthostatic hypotension at high doses

Pregnancy: can you take Beetroot juice / dietary nitrate (Beta vulgaris)?

Safe in usual dietary amounts. AESAN does not recommend high-dose nitrate supplements in gestation – nitrite excess may raise the fetal methaemoglobinaemia risk.

Breastfeeding: can you take Beetroot juice / dietary nitrate (Beta vulgaris)?

Compatible in usual dietary amounts. AESAN does not recommend high-dose nitrate supplements during lactation – methaemoglobinaemia risk in infants under 6 months.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

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Frequently asked

What is Beetroot juice / dietary nitrate (Beta vulgaris) used for?

Beetroot juice / dietary nitrate (Beta vulgaris) is evaluated for the following indications with varying evidence strength: Mild arterial hypertension (evidence tier C), Athletic endurance (evidence tier C), “Cardiovascular wellness” (marketing claim) (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Beetroot juice / dietary nitrate (Beta vulgaris)?

Common side effects of Beetroot juice / dietary nitrate (Beta vulgaris) (≥ 1 in 100): Pink or red urine and stool (beeturia) – harmless coloration by beetroot pigment, Abdominal discomfort, flatulence, Orthostatic hypotension at high doses. See the Safety section for uncommon and serious reactions.

Is Beetroot juice / dietary nitrate (Beta vulgaris) safe during pregnancy?

Safe in usual dietary amounts. AESAN does not recommend high-dose nitrate supplements in gestation – nitrite excess may raise the fetal methaemoglobinaemia risk.

Is Beetroot juice / dietary nitrate (Beta vulgaris) compatible with breastfeeding?

Compatible in usual dietary amounts. AESAN does not recommend high-dose nitrate supplements during lactation – methaemoglobinaemia risk in infants under 6 months.

Who should not take Beetroot juice / dietary nitrate (Beta vulgaris)?

Beetroot juice / dietary nitrate (Beta vulgaris) is contraindicated in: Combination with organic nitrates (nitroglycerin, isosorbide) – risk of severe hypotension; Combination with PDE-5 inhibitors (sildenafil, tadalafil, vardenafil); History of oxalate kidney stones – beetroot is high in oxalates; Severe arterial hypotension; Hypersensitivity to beetroot. Full list in the Safety section.

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