Rates drug efficacy and safety based on international guidelines and current evidence
Estimate in-hospital mortality risk for upper GI bleeding with 5 AIMS65 criteria: albumin, INR, mental status, BP, age.
Saltzman JR, Tabak YP, Hyett BH, et al. Gastrointest Endosc 2011;74:1215-24
10-year risk of first MI, fatal CHD or stroke from the AHA/ACC 2013 Pooled Cohort Equations. Ages 40–79.
Goff DC Jr et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. Circulation. 2014;129(25 Suppl 2):S49-S73.
St. John's wort is a potent inducer of the CYP3A4 enzyme (and of CYP2C9 and P-glycoprotein). After 1–2 weeks it speeds up the breakdown of Everolimus and lowers its blood level, weakening its effect.
St. John's wort is a potent inducer of the CYP3A4 enzyme (and of CYP2C9 and P-glycoprotein). After 1–2 weeks it speeds up the breakdown of Efavirenz and lowers its blood level, weakening its effect.
Five evidence tiers. From A – first-line in international guidelines – to F – proven harm How we rate →