Evidence-based medicine reference

Rates drug efficacy and safety based on international guidelines and current evidence

Drugs

Indication matrix for each drug. A–F ratings linked directly to Cochrane, NICE, WHO and specialist international associations

664 drugs

Abiraterone

L02BX03

AProstate cancer
FAthletic endurance

Alendronic acid

M05BA04

APostmenopausal osteoporosis
FAnti-aging and longevity

Amorolfine

D01AE16

AOnychomycosis
FSevere nail fungus: topical-only treatment attempt

Anastrozole

L02BG03

AER-positive breast cancer
FAthletic endurance

1,2-Hexanediol

CTopical

Butylene Glycol (1,3-Butanediol)

BTopical

Octanediol

CTopical

Cosmetic ingredients

Evidence base for cosmetic ingredients. Efficacy evaluated separately for topical, injectable and oral routes

Browse ingredients

Calculators

Clinical calculators and unit converters. Every formula is covered by unit tests with reference values from publications

77 calculators

AIMS65 calculator: in-hospital mortality risk for upper GI bleeding

Estimate in-hospital mortality risk for upper GI bleeding with 5 AIMS65 criteria: albumin, INR, mental status, BP, age.

Saltzman JR, Tabak YP, Hyett BH, et al. Gastrointest Endosc 2011;74:1215-24

ASCVD 10-year risk (Pooled Cohort Equations)

10-year risk of first MI, fatal CHD or stroke from the AHA/ACC 2013 Pooled Cohort Equations. Ages 40–79.

Goff DC Jr et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk. Circulation. 2014;129(25 Suppl 2):S49-S73.

Both nephrotoxic. Combined use gives additive AKI risk.

Amphotericin B causes hypokalaemia, which enhances digoxin binding to cardiomyocyte Na-K-ATPase and potentiates digoxin toxicity.

Interactions

Drug-drug interaction reference and drug-nutrient effects on vitamin and mineral absorption

Check a pair

ABCDF

Five evidence tiers. From A – first-line in international guidelines – to F – no evidence of efficacy How we rate →