Niacinamide

Vitamin B3 form with a wide action spectrum: brightens pigmentation, strengthens the barrier, minimizes pores, and reduces sebum production.

BrighteningBarrier repairAcne

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

RCTs confirm efficacy for acne, melasma, and enlarged pores. A 2021 meta-analysis showed comparable efficacy to clindamycin for mild-to-moderate acne. Depigmenting effect occurs via inhibition of melanosome transfer to keratinocytes.

Walocko FM et al. J Cosmet Dermatol. 2017;16(3):320-325.
Levin J et al. J Clin Aesthet Dermatol. 2011;4(12):19-31.

Working concentrations

2–10%

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Safe

Skin types

Suitable for

OilyCombinationSensitiveNormalDry

Combinations with other ingredients

Works well with

Zinc PCAЦинк PCA

Combination reduces sebum production and inflammation. Niacinamide regulates the barrier, zinc binds excess sebum.

Hyaluronic AcidГиалуроновая кислота

Safe pair for most routines. Niacinamide strengthens the barrier, hyaluronic acid retains water in the stratum corneum.

Azelaic AcidАзелаиновая кислота

Both molecules work against post-acne pigmentation and inflammation. Gentle tolerability even on reactive skin.

Salicylic AcidСалициловая кислота

Salicylic acid works on comedones, niacinamide on inflammation and barrier. Pair performs well in acne.

Centella AsiaticaЦентелла азиатская

Both molecules reduce redness and support the barrier. A base pair for sensitive skin.

Tranexamic AcidТранексамовая кислота

Synergy for melasma: tranexamic acid suppresses tyrosinase, niacinamide blocks melanosome transfer to keratinocytes.

L-Ascorbic Acid (Vitamin C)L-Аскорбиновая кислота (витамин C)

The old incompatibility myth is debunked. In modern formulas these ingredients work together, enhancing brightening and antioxidant effects.

RetinolРетинол

Niacinamide reduces retinol's irritation potential by strengthening the barrier without sacrificing efficacy.

Does not combine with

Glycolic AcidГликолевая кислота

When combined in one formula, niacinamide can convert to nicotinic acid (flush, redness). Rare in modern leave-on, but alternating is safer.

Frequently asked questions

Is Niacinamide safe during pregnancy?

Niacinamide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What skin types is Niacinamide for?

Niacinamide suits: oily, combination, sensitive, normal, dry.