N-Hydroxysuccinimide
An iron chelator. The maker links it to reduced dark circles via iron binding; independent data are limited. Well tolerated.
Evidence by route
Topical application
A chelator active. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
N-Hydroxysuccinimide is a molecule that cosmetics use as an iron chelator. The manufacturer links it to reduced dark circles: by binding iron released from blood under the thin skin of the eye area, it aims to soften the bluish-brown tone there. The mechanism is plausible, but real-world effectiveness is another matter. The available data come mainly from the manufacturer and independent data are scarce. Dark circles have many causes (pigment, vascularity, structural shadow), and a single chelator does not cover them all. It is reasonable to see it as a supporting active with a modest result, not a guaranteed fix. Applied topically its systemic absorption is minimal, so it can be used during pregnancy and breastfeeding. Tolerability is good, with low irritation and allergy potential. It suits the under-eye area and sensitive skin, with the usual care when applying near the eye.
Frequently asked questions
Is N-Hydroxysuccinimide safe during pregnancy?
N-Hydroxysuccinimide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is N-Hydroxysuccinimide for?
N-Hydroxysuccinimide suits: normal, dry, combination, oily, sensitive.
What is N-Hydroxysuccinimide and what does it do in cosmetics?
An iron chelator.
What's the INCI name for N-Hydroxysuccinimide?
The INCI name is N-Hydroxysuccinimide.
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