Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component. Reduces melanin synthesis in melanocytes. Pregnancy-safe.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Brightening peptide with confirmed α-MSH inhibition mechanism.
Nonapeptide-1 (Melitane) is a synthetic 9-amino-acid peptide, an antagonist of α-melanocyte-stimulating hormone (α-MSH). INCI: Nonapeptide-1. In cosmetics it works as a brightening agent. It blocks the α-MSH receptor MC1R on melanocytes, which reduces tyrosinase activation and melanin synthesis. An alternative to hydroquinone without irritating action. Used in products for hyperpigmentation, melasma and post-inflammatory spots. Use levels run from 0.1 to 2% active peptide. Pregnancy safety. Skin absorption into the systemic circulation is minimal. Skin profile. Low irritation and allergen potential. Non-comedogenic. Suitable for all skin types. Moderate evidence (B) – in vitro and small clinical data from the manufacturer.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Nonapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Nonapeptide-1 suits: normal, dry, combination, oily, sensitive.
Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component.
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
The INCI name is Nonapeptide-1. It may also appear as: Melitane, нонапептид-1.
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