Nonapeptide-1
Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component. Reduces melanin synthesis in melanocytes. Pregnancy-safe.
Evidence by route
Topical application
Brightening peptide with confirmed α-MSH inhibition mechanism.
- Lubrizol Melitane technical brochure and clinical data, 2016.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Nonapeptide-1 (Melitane) is a synthetic 9-amino-acid peptide, an antagonist of α-melanocyte-stimulating hormone (α-MSH). INCI: Nonapeptide-1. In cosmetics it works as a brightening agent. It blocks the α-MSH receptor MC1R on melanocytes, which reduces tyrosinase activation and melanin synthesis. An alternative to hydroquinone without irritating action. Used in products for hyperpigmentation, melasma and post-inflammatory spots. Use levels run from 0.1 to 2% active peptide. Pregnancy safety. Skin absorption into the systemic circulation is minimal. Skin profile. Low irritation and allergen potential. Non-comedogenic. Suitable for all skin types. Moderate evidence (B) – in vitro and small clinical data from the manufacturer.
Frequently asked questions
Is Nonapeptide-1 safe during pregnancy?
Nonapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Nonapeptide-1 for?
Nonapeptide-1 suits: normal, dry, combination, oily, sensitive.
What is Nonapeptide-1 and what does it do in cosmetics?
Synthetic 9-amino-acid peptide – an α-MSH receptor inhibitor, a brightening component.
Is Nonapeptide-1 comedogenic?
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
What's the INCI name for Nonapeptide-1?
The INCI name is Nonapeptide-1. It may also appear as: Melitane.
See Nonapeptide-1 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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