A patented brightening ingredient from La Roche-Posay (Mela B3 line). It targets hyperpigmentation by interfering with melanin transfer. The maker shows effect in its own trials; independent data are still limited.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A brightening active. Well tolerated; independent data still limited.
2-Mercaptonicotinoyl glycine (INCI: 2-Mercaptonicotinoyl Glycine) is a brightening active patented by La Roche-Posay and used in its Mela B3 line. It is designed to act on hyperpigmentation by interfering with the transfer of melanin to skin cells. On efficacy, transparency matters. The manufacturer shows results in its own clinical trials, which points to real action on dark spots, but independent evidence is still limited. For now it fits as a promising active backed mainly by the lab that developed it, not by the broad evidence base that ingredients like niacinamide carry. Applied topically no systemic relevance is expected, so it can be used during pregnancy and breastfeeding with the usual caution that applies to any brightening agent. The reported tolerance is good: low irritation potential and low allergy risk. Most skin types do not react, which fits its use in formulas aimed at sensitive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
2-Mercaptonicotinoyl Glycine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
2-Mercaptonicotinoyl Glycine suits: normal, dry, combination, oily, sensitive.
A patented brightening ingredient from La Roche-Posay (Mela B3 line).
The INCI name is 2-Mercaptonicotinoyl Glycine. It may also appear as: 2-Меркаптоникотиноил глицин.
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