Alpha-Arbutin

Synthetic arbutin analogue. Inhibits tyrosinase, reducing melanin synthesis without direct melanocyte cytotoxicity.

Brightening

Evidence by route

Topical application

Weak evidence. In vitro data, open-label studies, or expert consensus.

In vitro studies and small clinical trials confirm depigmenting effect. Large independent RCTs comparing with other agents (azelaic acid, tranexamic acid) are lacking. Stability in formulas at pH above 5 is questionable.

Sugimoto K et al. Chem Pharm Bull. 2005;53(9):1056-1059.

Working concentrations

1–3%

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Caution

Skin types

Suitable for

NormalDrySensitiveCombinationOily

Frequently asked questions

Is Alpha-Arbutin safe during pregnancy?

Alpha-Arbutin should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.

What skin types is Alpha-Arbutin for?

Alpha-Arbutin suits: normal, dry, sensitive, combination, oily.