Evigrade catalog. Every drug is evaluated per drug-indication pair against international clinical guidelines
Evidence scale
Direct serotonin precursor, supplement (not registered as medicine in EU or US)
N06AX-5HTP
4 indications
Androgen biosynthesis inhibitors
L02BX03
2 indications
NSAID, acetic acid derivative, COX-1/COX-2 inhibitor
M01AB16
4 indications
Acetylated ester of L-carnitine; supplement with claimed neurotropic effect
A16AA-ALCAR
4 indications
Mucolytic; paracetamol overdose antidote; glutathione precursor
R05CB01
5 indications
Antiplatelet agents (low dose) / NSAIDs (analgesic dose)
B01AC06
3 indications
Antiviral – nucleoside analogue
J05AB01
4 indications
Long-acting muscarinic antagonist for inhalation (LAMA)
R03BB05
3 indications
Biologic – tumor necrosis factor alpha (TNFα) inhibitor
L04AB04
4 indications
Amino acids and derivatives. Hepatoprotective agent
A16AA02
5 indications
Supplement of Allium sativum extract aged for 20 months and standardised to S-allylcysteine (SAC); sold under the Kyolic brand; not registered as a medicine by AEMPS
C04AB-AGED-GARLIC
3 indications
Antidepressant – melatonin agonist and 5-HT2C antagonist
N06AX22
2 indications
Nitrogen-containing bisphosphonate
M05BA04
2 indications
Immunomodulators, antivirals (local classification). Russian development.
L03AX-ALLOKIN
2 indications
Xanthine oxidase inhibitors
M04AA01
3 indications
Antacid (aluminium magnesium hydroxide carbonate)
A02AD02
3 indications
Selective serotonin 5HT1B/1D agonists (triptans)
N02CC05
3 indications
Antioxidant; cofactor of pyruvate and α-ketoglutarate dehydrogenase
A16AX-ALPHA-LIPOIC
5 indications
Fat-soluble vitamin E
A11HA03
3 indications
Benzodiazepines. Short-to-medium-acting anxiolytics
N05BA12
3 indications
Mucolytic agent
R05CB06
2 indications
Immunomodulators (local classification). Russian development.
L03AX-GALAVIT
2 indications
Class III antiarrhythmics (Vaughan Williams)
C01BD01
5 indications
Atypical antipsychotic of the benzamide class
N05AL05
2 indications
Tricyclic antidepressants (TCA)
N06AA09
5 indications
Calcium channel blockers (dihydropyridines)
C08CA01
3 indications
Fixed-dose combination: dihydropyridine calcium channel blocker plus angiotensin II receptor blocker
C09DB02
1 indication
Triple fixed-dose combination: dihydropyridine CCB, angiotensin II receptor blocker, and thiazide diuretic
C09DX03
1 indication
Fixed-dose combination: dihydropyridine calcium channel blocker plus angiotensin II receptor blocker
C09DB01
1 indication
Triple fixed-dose combination: dihydropyridine CCB, angiotensin II receptor blocker, and thiazide diuretic
C09DX01
1 indication
Topical antifungal (morpholine class)
D01AE16
2 indications
Penicillins with extended spectrum
J01CA04
6 indications
Fixed-dose combination: aminopenicillin plus beta-lactamase inhibitor
J01CR02
4 indications
Polyene systemic antifungal
J02AA01
1 indication
Homeopathic medicines
V03AX-ANAFERON
4 indications
Homeopathic products (local classification)
V03AX-OSCILLO
4 indications
Third-generation non-steroidal aromatase inhibitor
L02BG03
2 indications
Plant immunomodulator, supplement. In EU – traditional herbal medicinal product (EMA HMPC monograph 2013)
A11JA-ANDROGRAPHIS
4 indications
Homeopathic products (local classification)
V03AX-TENOTEN
4 indications
Flavonoid from chamomile, parsley and celery; supplement for sleep and «anti-ageing»; not registered as a drug by AEMPS or EMA; EFSA has not approved related health claims
N05CX-APIGENIN
3 indications
Direct oral anticoagulants (factor Xa inhibitors)
B01AF02
5 indications
Atypical antipsychotic – dopamine partial agonist
N05AX12
4 indications
Herbal preparation, supplement. In EU – traditional herbal medicinal product (EMA HMPC). In Russia OTC product Hofitol is registered
A11JA-ARTICHOKE
3 indications
Vitamins. Antioxidants
A11GA01
8 indications
Dietary supplements, plant adaptogens (local classification)
A11JA-ASHWAGANDHA
3 indications
Dietary supplements, carotenoids (local classification)
A11JA-ASTAXANTHIN
4 indications
Root of the perennial legume Astragalus membranaceus and its extracts. In traditional Chinese medicine, Huang Qi is used to «tonify Qi»; modern marketing sells it as an «immune modulator», a «longevity and telomere supplement», and supportive care in oncology. Neither AEMPS nor EMA registers it as a medicine; the EMA HMPC has not published a dedicated monograph on astragalus. AESAN classifies it as a complemento alimenticio. FDA has issued no approval.
A16AX-ASTRAGALUS
3 indications
Antiretroviral, HIV protease inhibitor
J05AE08
1 indication
Selective beta-1 adrenergic blocker
C07AB03
2 indications
Centrally acting sympathomimetics
N06BA09
2 indications
HMG-CoA reductase inhibitors (statins)
C10AA05
4 indications
Fixed-dose combination: statin plus intestinal cholesterol absorption inhibitor
C10BA05
2 indications
Immunosuppressants, thiopurines
L04AX01
3 indications
Macrolides
J01FA10
5 indications
Other immunostimulants (local classification)
L03AX-POLYOXIDONIUM
5 indications
Plant nootropic adaptogen from Ayurvedic medicine, supplement. Not registered as medicine in EU or AEMPS
A11JA-BACOPA
4 indications
Other immunostimulants
L03AX-OM85
3 indications
Inhaled corticosteroids (ICS)
R03BA01
2 indications
Food product rich in inorganic nitrate; sold as a sports supplement and a «biohack» BP-lowering aid; not registered as a medicine by AEMPS
C09BX-BEETROOT
3 indications
Dietary supplements, plant alkaloids (local classification)
A07AA-BERBERINE
4 indications
Polysaccharide immunomodulator. Oat beta-glucan is a dietary fibre with EFSA-approved cholesterol health claim. Yeast beta-glucan (Wellmune) is a supplement with immunity marketing without EFSA approval
A11JA-BETA-GLUCAN
5 indications
Non-essential beta-amino acid, carnosine precursor. Supplement with IOC 2018 proven efficacy for 1-4 minute anaerobic performance
A16AA-BETA-ALANINE
2 indications
Provitamin A (plant precursor of retinol)
A11CA02
3 indications
Leucine metabolite, sport supplement and for sarcopenia. AEMPS does not register as medicine
A16AA-HMB
2 indications
Histamine analogue, antivertigo agent
N07CA01
3 indications
Methyl donor; agent for the alternative homocysteine remethylation pathway
A16AA06
4 indications
Over-the-counter supplement, an acidic salt of betaine (trimethylglycine hydrochloride); marketed as a gastric acid replacement for «low stomach acid»; commonly combined with pepsin on iHerb and Amazon
A09AB-BETAINE-HCL
3 indications
Non-steroidal antiandrogen
L02BB03
2 indications
Probiotic, Bifidobacterium genus bacteria. Supplement in Russia and Spain; marketing segment of «psychobiotics» promising gut-brain axis effects. AEMPS does not register it as a medicine
A07FA-BLONGUM
4 indications
Second-generation antihistamine
R06AX29
3 indications
Herbal preparation, EMA HMPC traditional herbal medicinal product
A11JA-BILBERRY
3 indications
Topical prostamide / prostaglandin F2α analogue for ophthalmic use
S01EE03
3 indications
Vitamin B7 (H). Water-soluble vitamin, cofactor of four carboxylases. AEMPS registers biotin as a medicine for treating confirmed deficiency; in multivitamins and mono-supplements – dietary supplement
A11HA05
3 indications
Stimulant laxatives
A06AB02
2 indications
Selective beta-adrenergic blockers
C07AB07
5 indications
Herbal product for menopausal symptoms (food supplement under Spanish RD 1487/2009)
G02CX-CIMICIFUGA
2 indications
Seeds of the annual herb Nigella sativa and cold-pressed oil from them. Arabic and Indian traditional medicine used black seed for colds, parasites, diabetes, and skin disease. Modern supplement marketing sells it as an «immune booster», «natural insulin», «cancer remedy», and «general tonic». Neither AEMPS nor EMA registers it as a medicine; AESAN classifies it as a complemento alimenticio without therapeutic indication. FDA has issued no approval and the EMA HMPC has not published a monograph on Nigella sativa.
A16AX-NIGELLA
3 indications
Botanical supplement, black seed oil (Nigella sativa, thymoquinone); no EMA HMPC monograph
A11JA-NIGELLA
3 indications
Trace element with no established human biological role, supplement
A12CX-BORON
2 indications
Botanical supplement, gum resin of Boswellia serrata (Indian frankincense), standardised by AKBA (acetyl-11-keto-beta-boswellic acid); popular iHerb «joint health» category
M01AX-BOSWELLIA
2 indications
Topical selective α2-adrenergic agonist for ophthalmic use
S01EA05
3 indications
Anxiolytics, benzodiazepine derivatives
N05BA08
2 indications
Proteolytic enzyme from Ananas comosus pineapple stem and fruit. EU registered NexoBrid (concentrate of proteolytic enzymes enriched in bromelain, EMA 2012) for enzymatic deep burn excision topical. Oral – supplement. AEMPS registered NexoBrid for specialised burn centre use
A09AA-BROMELAIN
3 indications
Mucolytic agent
R05CB02
2 indications
Dopamine D2 receptor agonist, ergot derivative
N04BC01
1 indication
Inhaled corticosteroids (ICS)
R03BA02
5 indications
Inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA) combination with rapid onset
R03AK07
3 indications
Opioid analgesic – partial μ-opioid receptor agonist
N02AE01
2 indications
Other antidepressants (NDRI)
N06AX12
3 indications
Long-acting dopamine D2 receptor agonist, ergot derivative
N04BC06
1 indication
Vitamin D analogue (25-hydroxy metabolite)
A11CC06
3 indications
Topical antipsoriatic, synthetic vitamin D3 analogue
D05AX02
2 indications
Mineral supplements. Calcium
A12AA-CALCIUM
4 indications
Fixed-dose combination: calcium salt (carbonate) plus vitamin D3
A12AX
2 indications
Mineral supplements. Calcium
A12AA04
5 indications
Calcium salt of D-glucaric acid (food supplement under Spanish RD 1487/2009)
A12AX-CDG
2 indications
Capillary-stabilizing and venoactive agent
C05BX01
2 indications
Angiotensin II receptor blocker
C09CA06
5 indications
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA06
1 indication
Selective TRPV1 agonist, topical analgesic for neuropathic pain
N01BX04
4 indications
ACE inhibitor
C09AA01
4 indications
Antiepileptics. Carboxamide derivatives
N03AF01
5 indications
Mucolytic agent
R05CB03
2 indications
Alpha and beta blocker (non-selective β + α1)
C07AG02
1 indication
Botanical supplement, bark of the Uncaria tomentosa vine (cat's claw, una de gato) from Peruvian and Ecuadorian Amazonia; sold on iHerb for immunity, used in Peru for rheumatic pain and peptic ulcer
L03AX-CATS-CLAW
2 indications
First-generation cephalosporin
J01DB01
1 indication
Third-generation oral cephalosporin
J01DD16
4 indications
Third-generation cephalosporins
J01DD04
2 indications
Second-generation oral cephalosporin
J01DC02
4 indications
Selective COX-2 inhibitor (coxib)
M01AH01
1 indication
Other metabolic agents (local classification)
V03AX-CEREBROLYSIN
2 indications
Second-generation antihistamines
R06AE07
7 indications
Medicinal mushroom parasitising birch. In Russia OTC «Befungin» registered, in the West – supplement. AEMPS does not register as medicine
A11JA-CHAGA
3 indications
Herbal preparation, EMA HMPC traditional herbal medicinal product
N05CX-CHAMOMILE
3 indications
Freshwater unicellular green alga (Chlorella vulgaris / pyrenoidosa), supplement, marketed for «mercury detox»
A11JA-CHLORELLA
2 indications
Biguanide antiseptic for skin and mucous membranes
D08AC02
2 indications
Plant pigment; in supplements as natural chlorophyll (E140) and the water-soluble copper-sodium complex chlorophyllin (E141). In the European Union it is registered as a food colourant under Regulation (EC) 1333/2008. On iHerb, Amazon and in Spanish herbolarios «liquid chlorophyll» is sold as detox, a source of «liquid sunshine», anti-age, and an acne remedy. AEMPS does not register it as a medicine; AESAN classifies it as a complemento alimenticio without therapeutic indication. FDA has a single OTC-approved use – internal deodorant for ostomy, ileostomy, and incontinence (21 CFR 357.850, Derifil 100 mg)
A16AX-CHLOROPHYLL
5 indications
First-generation moderately sedating antihistamine
R06AB04
2 indications
Combined supplement: fat-soluble vitamins D3 and K2
A11AX-D3K2
4 indications
Essential nutrient-like substance; precursor of acetylcholine and phosphatidylcholine
A11JA-CHOLINE
4 indications
Other nervous system drugs. Parasympathomimetics
N07AX02
4 indications
Choline precursor, nootropic. Prescription medicine in Italy (Gliatilin, Italfarmaco); not authorised by AEMPS in Spain, sold as a dietary supplement via parafarmacia. Registered as a medicine in Russia (Tsereton, Gliatilin import)
N06BX-ALPHA-GPC
6 indications
Essential nutrient, dietary supplement. The basic choline form used in supplements. Not registered as a medicine in the EU or USA; sold as a supplement in Russia
N06BX-CHOLINE-BITARTRATE
4 indications
Trace mineral, supplement marketed for blood sugar control and weight loss
A12CX-CHROMIUM
2 indications
Topical antifungal (hydroxypyridone class)
D01AE14
1 indication
Immunosuppressants. Calcineurin inhibitors
L04AD01
6 indications
Benzamide prokinetic with combined serotonin and dopamine receptor activity
A03FA06
2 indications
Calcium channel blocker with antihistamine activity
N07CA02
2 indications
Fluoroquinolone antibacterials
J01MA02
4 indications
Prokinetic, 5-HT4 serotonin receptor agonist (withdrawn EU/US)
A03FA02
1 indication
SSRI (selective serotonin reuptake inhibitor)
N06AB04
1 indication
Other psychostimulants and nootropics
N06BX06
4 indications
Macrolide antibiotic
J01FA09
4 indications
Lincosamide antibiotic
J01FF01
1 indication
1,5-benzodiazepine antiepileptic
N05BA09
2 indications
Central α2-adrenergic agonist
C02AC01
1 indication
Antiplatelet agents – P2Y12 receptor inhibitors
B01AC04
4 indications
Imidazole derivatives, topical antifungals
G01AF02
2 indications
Atypical antipsychotic – dibenzodiazepine
N05AH02
2 indications
Sulfonamide-trimethoprim combination
J01EE01
5 indications
Pharmacokinetic enhancer (booster) for antiretroviral therapy
V03AX03
1 indication
Cod liver oil: EPA and DHA combined with retinol (vitamin A) and cholecalciferol (vitamin D3); registered as a medicine in Spain
C10AX-COD-LIVER
3 indications
Antigout agents
M04AC01
3 indications
Vitamins. Regulator of calcium-phosphorus metabolism
A11CC05
7 indications
Mixture of positional and geometric linoleic acid isomers; supplement for «fat burning» and sports nutrition; not registered as a medicine by AEMPS
A08AX-CLA
2 indications
Trace cofactor mineral, used in parenteral nutrition and supplements
A12CX-COPPER
2 indications
Non-hormonal intrauterine contraceptive device
G02BA02
3 indications
Medicinal mushroom of Tibetan and Chinese medicine, supplement. AEMPS does not register as medicine
A11JA-CORDYCEPS
4 indications
Other psychostimulants and nootropics (local classification)
N06BX-CORTEXIN
9 indications
mRNA SARS-CoV-2 vaccine
J07BX03
2 indications
mRNA SARS-CoV-2 vaccine
J07BX03
3 indications
Herbal preparation for recurrent urinary tract infection prevention. In EU – traditional herbal medicinal product (EMA HMPC). AEMPS does not register as medicine; sold as supplement
A11JA-CRANBERRY
1 indication
Dietary supplements, sports nutraceuticals (local classification)
A11JA-CREATINE
3 indications
Herbal anti-inflammatory agents
A07XA-CURCUMIN
5 indications
Vitamins. Haemopoietic stimulants
B03BA01
3 indications
Antiandrogen with progestogenic activity
G03HA01
4 indications
Antiandrogenic COC
G03HB01
2 indications
Other metabolic agents (local classification)
A16AX-CYTOFLAVIN
3 indications
D-enantiomer of aspartic acid, sport and biohacking supplement. AEMPS does not register as medicine
A16AA-D-ASPARTIC
2 indications
Inositol stereoisomer, supplement. Usually used combined with myo-inositol in 40:1 ratio
A11JA-D-CHIRO-INOSITOL
2 indications
Pentose monosaccharide; complemento alimenticio with a claimed role in energy metabolism
A11JA-DRIBOSE
4 indications
Direct thrombin inhibitor
B01AE07
3 indications
Sodium-glucose cotransporter-2 (SGLT2) inhibitor
A10BK01
4 indications
Cyclic lipopeptide antibiotic
J01XX09
1 indication
Second-generation HIV protease inhibitor
J05AE10
1 indication
Iron chelating agents
V03AC03
2 indications
Systemic glucocorticoid (oxazoline derivative)
H02AB13
3 indications
Over-the-counter botanical supplement, an extract of Glycyrrhiza glabra root with glycyrrhizin removed (to eliminate the mineralocorticoid effect); marketed for peptic ulcer, functional dyspepsia and H. pylori
A02BX-DGL
3 indications
Endogenous C19 steroid precursor; an EU prescription drug for adrenal insufficiency and a vaginal form (Intrarosa); a freely available supplement in the United States
A14AA-DHEA
5 indications
Biologic – RANKL inhibitor
M05BX04
2 indications
Other metabolic agents (local classification)
V03AX-ACTOVEGIN
3 indications
Second-generation antihistamine
R06AX27
3 indications
Progestogen-only pill (POP)
G03AC09
2 indications
Glucocorticoids
H02AB02
4 indications
First-generation sedating antihistamine
R06AB02
3 indications
Non-steroidal anti-inflammatory drugs, propionic acid derivatives
M01AE17
2 indications
Centrally acting cough suppressant
R05DA09
2 indications
Anxiolytics. Benzodiazepine derivatives
N05BA01
6 indications
Non-steroidal anti-inflammatory drugs (NSAIDs)
M01AB05
5 indications
Cardiac glycosides (digitalis)
C01AA05
4 indications
Ergot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist
N02CA01
1 indication
Indole-3-carbinol metabolite from cruciferous vegetables, supplement. AEMPS does not register as medicine
A11JA-DIM
2 indications
Calcium channel blocker, non-DHP (benzothiazepine derivative)
C08DB01
1 indication
Immunomodulator for disease-modifying therapy of multiple sclerosis
L04AX07
2 indications
Intestinal adsorbents (natural smectite)
A07BC05
3 indications
Micronized purified flavonoid fraction, «venoactive» agent
C05CA53
2 indications
First-generation sedating antihistamine
R06AA02
2 indications
Class Ia antiarrhythmic with antimuscarinic activity
C01BA03
1 indication
Drug for alcohol use disorder, aldehyde dehydrogenase inhibitor
N07BB01
1 indication
Class III antiarrhythmic, selective IKr blocker
C01BD04
1 indication
Prokinetic, peripheral dopamine D2 receptor antagonist
A03FA03
2 indications
Selective reversible acetylcholinesterase inhibitor
N06DA02
3 indications
Traditional Chinese medicine herbal product (food supplement under Spanish RD 1487/2009)
G02CX-DONG-QUAI
2 indications
Topical carbonic anhydrase II inhibitor for ophthalmic use
S01EC03
3 indications
Long-acting selective α1-adrenoceptor antagonist
C02CA04
3 indications
Tetracyclines
J01AA02
5 indications
First-generation antihistamine (ethanolamine); antiemetic in combination with pyridoxine
A04AD51
2 indications
Combination of H1-antihistamine and vitamin B6
R06AA09
3 indications
Class III antiarrhythmic
C01BD07
3 indications
Combined oral contraceptives — antimineralocorticoid progestin
G03AA12
4 indications
Myotropic antispasmodics
A03AD02
3 indications
SNRI
N06AX21
1 indication
Testosterone 5α-reductase types 1 and 2 inhibitors
G04CB02
3 indications
Fixed-dose combination: 5-alpha-reductase inhibitor plus selective alpha-1a-adrenoceptor blocker
G04CA52
1 indication
Progestogens — pregnadiene derivatives
G03DB01
4 indications
Second-generation antihistamine
R06AX22
3 indications
Herbal immunomodulators (local classification)
L03AX-ECHINACEA
3 indications
Antiretroviral, non-nucleoside reverse transcriptase inhibitor (NNRTI)
J05AG03
1 indication
Plant immunomodulator, supplement. In EU – traditional herbal medicinal product (EMA HMPC monograph on flowers, berries classified as food)
A11JA-ELDERBERRY
3 indications
Triptan, selective 5HT1B/1D receptor agonist
N02CC06
1 indication
Plant adaptogen, supplement. In EU – traditional herbal medicinal product (EMA HMPC); OTC tincture in Russia
A11JA-ELEUTHEROCOCCUS
4 indications
Thrombopoietin receptor agonist (TPO-R)
B02BX05
2 indications
Sodium-glucose co-transporter 2 inhibitors (SGLT2i)
A10BK03
4 indications
Angiotensin-converting enzyme inhibitors (ACEi)
C09AA02
5 indications
Fixed-dose combination: ACE inhibitor plus thiazide diuretic
C09BA02
1 indication
Low-molecular-weight heparin (LMWH)
B01AB05
3 indications
Guanosine nucleoside analogue, anti-HBV agent
J05AF10
1 indication
Catechin polyphenol from green tea (Camellia sinensis), supplement. EFSA 2018 limited safe dose from supplements to 800 mg/day due to hepatotoxicity
A11JA-EGCG
4 indications
Selective mineralocorticoid receptor antagonist
C03DA04
3 indications
Homeopathic preparation marketed as an immunomodulator (local classification)
V03AX-ERGOFERON
4 indications
Ergot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist
N02CA02
1 indication
Macrolide antibiotic
J01FA01
2 indications
Selective serotonin reuptake inhibitors (SSRIs)
N06AB10
4 indications
Antiepileptic, carboxamide derivative
N03AF04
2 indications
Drugs for peptic ulcer and GORD. Proton pump inhibitors
A02BC05
6 indications
Liver therapy (local classification)
A05BA-ESSENTIALE
3 indications
Estrogens — natural and semisynthetic
G03CA03
4 indications
Monophasic COC with natural estrogen
G03AA14
2 indications
COC with natural estrogen (quadriphasic)
G03AA16
3 indications
Estrogens. Natural and semisynthetic estrogens, plain
G03CA01
5 indications
Combined oral contraceptives (COC), third generation
G03AA09
2 indications
COC third generation with gestodene
G03AA10
2 indications
Combined oral contraceptives (COC), second generation
G03AA07
3 indications
COC with norgestimate
G03AA11
2 indications
Other metabolic agents (local RU classification)
V03AX-MEXIDOL
4 indications
Subcutaneous long-acting hormonal implant (LARC)
G03AC08
2 indications
Combined hormonal contraceptive, vaginal route
G02BB01
2 indications
Selective COX-2 inhibitor (coxib)
M01AH05
4 indications
mTOR kinase inhibitor – immunosuppressant and antineoplastic
L01EG02
4 indications
Steroidal aromatase inhibitors
L02BG06
2 indications
Selective intestinal cholesterol absorption inhibitor
C10AX09
2 indications
Other anxiolytics (local classification)
N05BX-AFOBAZOLE
4 indications
Antiviral nucleoside analogue for herpes infections (HSV-1, HSV-2, VZV)
J05AB09
5 indications
H2-histamine receptor antagonist
A02BA03
3 indications
Selective xanthine oxidase inhibitor
M04AA03
2 indications
Opioid analgesic – synthetic μ-opioid receptor agonist
N02AB03
2 indications
Muscarinic receptor antagonist for overactive bladder
G04BD11
3 indications
Second-generation antihistamine
R06AX26
3 indications
Testosterone 5α-reductase type 2 inhibitors
G04CB01
3 indications
Plant flavonol, supplement. Natural polyphenol from strawberries, mangoes, onions, apples. The biohacking industry positions it as a «senolytic» – an agent that clears senescent cells
A11JA-FISETIN
3 indications
Class Ic antiarrhythmic
C01BC04
2 indications
Beta-lactamase-resistant penicillin
J01CF05
1 indication
Antifungals, triazole derivatives
J02AC01
4 indications
Selective calcium channel blocker, antivertigo and migraine prophylaxis agent
N07CA03
3 indications
Selective serotonin reuptake inhibitors
N06AB03
4 indications
Inhaled and intranasal corticosteroid
R03BA05
3 indications
Intranasal corticosteroid
R01AD12
3 indications
Inhaled corticosteroids (ICS)
R03BA05
3 indications
Statin (HMG-CoA reductase inhibitor)
C10AA04
2 indications
SSRI
N06AB08
1 indication
Vitamins. Haemopoietic stimulants
B03BB01
5 indications
Recombinant follicle-stimulating hormone (FSH)
G03GA05
1 indication
Long-acting selective β2-agonist with rapid onset (rapid-onset LABA)
R03AC13
3 indications
Other antibacterials
J01XX01
2 indications
Triptan, selective 5HT1B/1D receptor agonist
N02CC07
1 indication
Loop diuretics
C03CA01
7 indications
Gabapentinoids (antiepileptics)
N03AX12
5 indications
Acetylcholinesterase inhibitor with allosteric nicotinic modulation
N06DA04
2 indications
Inhibitory CNS neurotransmitter; as a supplement – amino acid for oral use
A16AA-GABA
3 indications
Plant extract of Garcinia gummi-gutta (cambogia) fruits; weight-loss supplement; not registered as a medicine by AEMPS; FDA Safety Communications 2009 and 2017 on hepatotoxicity
A08AX-GARCINIA
2 indications
Aminoglycoside antibiotic
J01GB03
5 indications
Herbal agents for cognitive disorders
N06BX02
6 indications
Oral hypoglycemic agents. Sulfonylureas
A10BB01
4 indications
Sulfonylureas
A10BB09
2 indications
Third-generation sulfonylurea
A10BB12
2 indications
Water-soluble dietary fibre from konjac root (Amorphophallus konjac); the only weight-loss supplement with an EFSA-approved health claim under Regulation 432/2012
A08AX-GLUCOMANNAN
3 indications
Aminomonosaccharide; supplement / OTC product positioned as a chondroprotective agent
M01AX05
1 indication
Chondroprotector. Glucosamine sulfate and chondroitin sulfate as monoproducts are registered by AEMPS as medicines for symptomatic treatment of mild-to-moderate knee osteoarthritis (Xicil, Pharma Mar; Condrosulf, Condrosan, Bioiberica). Fixed combinations are more often dietary supplements. In Russia, Dona and Structum are registered as medicines
M01AX05
3 indications
Other immunostimulants (local classification)
L03AX-LIKOPID
3 indications
Tripeptide antioxidant (γ-glutamyl-cysteinyl-glycine); cofactor of glutathione S-transferase
A16AX
5 indications
Other psychostimulants and nootropics (local classification)
N06BX-GLYCINE
6 indications
Liver therapy (local classification, «hepatoprotectors»)
A05BA-PHOSPHOGLIV
4 indications
5HT3 serotonin receptor antagonist
A04AA02
2 indications
Plant polyphenol complex, supplement. Source of oligomeric proanthocyanidins (OPC), compositionally similar to pycnogenol
A11JA-GRAPE-SEED
4 indications
First-generation antipsychotics. Butyrophenone derivatives
N05AD01
5 indications
Medicinal plant; EMA HMPC well-established use for mild nervous tension and traditional use in mild chronic heart failure; standardised WS 1442 extract (Crataegutt)
C01EB-HAWTHORN
3 indications
Inactivated viral vaccine
J07BC02
1 indication
Recombinant protein vaccine
J07BC01
1 indication
Bioflavonoid, «venoactive» agent
C05CA05
1 indication
Plant adaptogen from Ayurvedic medicine, supplement. Not registered as medicine in EU or AEMPS
A11JA-TULSI
3 indications
Nootropics (local classification). Russian and Japanese development.
N06BX-HOPANTENIC
3 indications
Botanical supplement, aerial parts of Equisetum arvense (field horsetail), source of silica and flavonoids; in the EU registered as a traditional-use herbal medicinal product (EMA HMPC) for mild diuretic effect; sold on iHerb as silica for «skin, hair and nails»
A11JA-HORSETAIL
2 indications
Recombinant protein vaccine, VLP
J07BM02
1 indication
Alkaloid of Chinese club moss (Huperzia serrata, Lycopodium serratum), a selective reversible acetylcholinesterase inhibitor. Registered as a prescription medicine Shuangyiping for Alzheimer disease in China. No marketing authorisation in the EU or USA; sold as a dietary supplement
N06BX-HUPERZINE-A
4 indications
Dietary supplement. Glycosaminoglycan produced by bacterial fermentation of Streptococcus zooepidemicus. AEMPS does not register oral hyaluronic acid as a medicine; intra-articular and topical forms (M09AX01, S01KA01) are registered medicines
V06DX-HYALORAL
3 indications
Direct arteriolar vasodilator
C02DB02
2 indications
Thiazide diuretics
C03AA03
3 indications
Short-acting systemic glucocorticoid, identical to endogenous cortisol
H02AB09
2 indications
Dietary supplement, hydrolysate of animal or marine connective tissue. In Russia and Spain sold as dietary supplement. AEMPS does not register oral collagen as a medicine
V06DX-COLLAGEN
4 indications
Vitamin B12 (European form of choice) and cyanide poisoning antidote
B03BA03
3 indications
Antimalarials, aminoquinolines
P01BA02
4 indications
First-generation antihistamine with anxiolytic activity
N05BB01
2 indications
Antispasmodic, quaternary ammonium belladonna alkaloid
A03BB01
3 indications
Antidepressants. Other antidepressants of herbal origin
N06AX25
3 indications
Non-steroidal anti-inflammatory drugs (NSAIDs)
M01AE01
5 indications
Other oral cavity preparations (local classification)
R02AA-IMUDON
3 indications
Inactivated subunit or split influenza vaccine
J07BB02
3 indications
Thiazide-like diuretics
C03BA11
3 indications
Plant indole derivative from cruciferous vegetables (food supplement under Spanish RD 1487/2009)
A11JA-I3C
2 indications
Other antivirals with claimed immunostimulant effect
J05AX05-INOSINE-PRANOBEX
3 indications
Insulins and analogues (general card; individual products require separate cards)
A10A
3 indications
Other topical nasal preparations (local classification)
R01AX-GRIPPFERON
4 indications
Interferons (suppositories, local classification)
L03AB05-VIFERON
4 indications
Soluble fructan fibre, prebiotic. Supplement in Russia and Spain. EFSA approved health claim for chicory inulin on maintenance of normal defecation (2015). AEMPS does not register it as a medicine
A06AC-INULIN
4 indications
Trace element; substrate of thyroid hormone synthesis
H03CA-IODINE
5 indications
X-ray contrast media. Watersoluble nephrotropic low-osmolar iodinated agents
V08AB05
4 indications
Short-acting muscarinic antagonist for inhalation (SAMA)
R03BB01
4 indications
Angiotensin II receptor blocker (ARB, sartan)
C09CA04
2 indications
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA04
1 indication
Oral iron preparations; antianaemic agents
B03AA
4 indications
Organic nitrate, nitric oxide donor
C01DA08
1 indication
Long-acting organic nitrate
C01DA14
3 indications
Systemic retinoid (vitamin A derivative)
D10BA01
1 indication
Antifungal, triazole
J02AC02
3 indications
Selective If channel inhibitor of the sinoatrial node
C01EB17
3 indications
Other antivirals (local classification)
J05AX-KAGOCEL
4 indications
Systemic antimycotics. Imidazole derivatives
J02AB02
4 indications
Non-steroidal anti-inflammatory drugs (NSAIDs)
M01AB15
3 indications
Antihistamine + mast cell stabilizer
R06AX17
2 indications
Phospholipid-bound omega-3 (EPA and DHA) with astaxanthin from Antarctic krill Euphausia superba, supplement
C10AX-KRILL
2 indications
Conditionally essential amino acid, NO precursor. Sport and cardio-biohacking supplement. AEMPS does not register as medicine
A16AA-L-ARGININE
3 indications
Non-essential amino acid and urea-cycle intermediate. Normally produced in liver and gut from glutamine and converted in plasma to L-arginine and then nitric oxide (NO). Supplements market it as a «natural Viagra alternative», a «pump» agent for bodybuilders (vasodilation and muscle blood flow), and a remedy for blood pressure and cardiovascular health. Neither AEMPS nor EMA register it as a medicine; a specialty product (citrulline malate) exists for mitochondrial disorders and urea-cycle defects, but it is a specialised drug, not a supplement. AESAN classifies regular L-citrulline supplements as complementos alimenticios. FDA has issued no supplement approval.
A16AX-CITRULLINE
5 indications
Conditionally essential amino acid; the main nitrogen source for nucleotide synthesis and fuel for enterocytes and immune cells. Normally supplied by dietary protein (meat, fish, eggs, dairy, legumes) and synthesised in skeletal muscle. Supplements market it as a remedy for «leaky gut», post-workout recovery, immune support in cancer patients, and a sugar-craving reducer. Neither AEMPS nor EMA registers it for supplement indications; a specialty drug exists (Endari, L-glutamine, FDA-approved) for sickle-cell disease to reduce pain-crisis frequency – this is a specialised clinical niche, not a supplement. AESAN classifies general L-glutamine supplements as complementos alimenticios.
A16AX-GLUTAMINE
6 indications
Essential amino acid
A16AA-L-LYSINE
2 indications
Urea cycle amino acid, adjunct for hyperammonaemia
A16AA-L-ORNITHINE
2 indications
Amino acid from green tea leaves (Camellia sinensis), supplement
A16AA-L-THEANINE
3 indications
Combined metabolic preparations (local classification). Russian development.
A11JA-BIOTREDIN
3 indications
Essential amino acid, precursor of serotonin, melatonin and niacin. In the UK registered by MHRA as Optimax for resistant depression
N06AX02
4 indications
Conditionally essential amino acid, precursor of catecholamines and thyroid hormones
A16AA-L-TYROSINE
2 indications
Alpha- and beta-blocker
C07AG01
2 indications
Antiepileptic – selective sodium channel modulator
N03AX18
2 indications
Probiotic, Lacticaseibacillus rhamnosus GG strain. Supplement in Russia and Spain; in the EU and US available as food supplement or medical food; AEMPS does not register it as a medicine
A07FA-LGG
6 indications
Bovine colostrum and human-milk glycoprotein supplement marketed as «immune modulator», «iron support» and «antiviral»
J05AX-LACTOFERRIN
3 indications
Antiepileptic with dual mechanism
N03AX09
3 indications
Proton pump inhibitor (PPI)
A02BC03
3 indications
Prostaglandin analogues, antiglaucoma agents
S01EE01
2 indications
Phospholipid mixture, dietary supplement. A mass OTC «memory drug» and «hepatoprotector» in Russia. Essentiale (Sanofi, essential phospholipids) is a separate regulated medicine, registered by AEMPS and in Russia for NAFLD
A11JA-LECITHIN
5 indications
Selective immunosuppressants
L04AA13
2 indications
Immunomodulatory drug (IMiD), thalidomide derivative
L04AX04
2 indications
Third-generation dihydropyridine calcium channel blocker
C08CA13
2 indications
Third-generation non-steroidal aromatase inhibitor
L02BG04
2 indications
Antiepileptics (other)
N03AX14
3 indications
Amino acid derivative; cofactor for long-chain fatty acid transport into mitochondria
A16AA01
5 indications
Second-generation antihistamine
R06AE09
3 indications
Triple fixed-dose combination: dopamine precursor, peripheral decarboxylase inhibitor, and COMT inhibitor
N04BA03
1 indication
Third-generation fluoroquinolone
J01MA12
4 indications
Active form of vitamin B9, ready for methylation reactions
B03BB-METHYLFOLATE
5 indications
Progestogen-only contraceptive (POP + emergency contraception)
G03AC03
2 indications
Long-acting intrauterine hormonal system (LARC)
G02BA03
3 indications
Thyroid hormones
H03AA01
4 indications
Root of Glycyrrhiza glabra and related Glycyrrhiza uralensis and Glycyrrhiza inflata species. Supplements come as root extract, candy, tea, alcoholic tincture, and deglycyrrhizinated form (DGL, without glycyrrhizin). Marketing promotes licorice as «adrenal support», a remedy for «adrenal fatigue», and a «natural remedy for viruses and gastritis». EMA HMPC published a European herbal monograph (2013) with traditional uses in cough, dyspepsia, and skin irritation; AEMPS does not register it as a medicine; AESAN classifies it as a complemento alimenticio. FDA grants GRAS status as a food additive but in 2017 warned consumers of cardiac arrhythmia risk with intake above 56 g/day of black licorice candy in people over 40.
A16AX-LICORICE
3 indications
Dipeptidyl peptidase 4 (DPP-4) inhibitor – gliptin
A10BH05
1 indication
Oxazolidinone antibiotic
J01XX08
4 indications
Medicinal mushroom, supplement. AEMPS does not register as medicine
A11JA-LIONS-MANE
3 indications
Medicinal mushroom; in supplements – dried mycelium or fruiting body of Hericium erinaceus. Marketed on iHerb, Amazon, and in Spanish herbolarios as a «natural nootropic», nerve growth factor (NGF) stimulant, and remedy for dementia, anxiety, and ADHD. AEMPS does not register it as a medicine; AESAN classifies it as a complemento alimenticio without therapeutic indication. FDA has no approved indication.
A16AX-LION-MANE
4 indications
Glucagon-like peptide-1 (GLP-1) receptor agonist
A10BJ02
3 indications
ACE inhibitors
C09AA03
2 indications
Psycholeptics. Lithium
N05AN01
4 indications
Antipropulsives
A07DA03
4 indications
Second-generation antihistamines
R06AX13
6 indications
Anxiolytics, benzodiazepine derivatives
N05BA06
3 indications
Intermediate-acting benzodiazepine hypnotic
N05CD06
2 indications
Angiotensin II receptor blockers (sartans)
C09CA01
4 indications
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA01
1 indication
HMG-CoA reductase inhibitor (statin)
C10AA02
2 indications
Xanthophyll carotenoid, supplement marketed for vision and skin support
A11JA-LUTEIN
3 indications
Carotenoids. Antioxidants for vision
S01XA-LUTEIN
3 indications
Tetraterpene carotenoid; pigment of tomatoes, rosehip, watermelon and grapefruit; sold as a supplement and as the food colorant E160d; not registered as a medicine by AEMPS
A11JA-LYCOPENE
3 indications
Botanical supplement, Peruvian maca root (Lepidium meyenii), marketed for male and female sexual function
A11JA-MACA
2 indications
Mineral supplements. Macrominerals
A12CC-MAGNESIUM
5 indications
Magnesium chelate with L-threonic acid in a specific stoichiometry; the patented Magtein form, developed as a Stanford / MIT spinout; sold as a «magnesium for the brain» supplement
A12CC-MG-L-THREONATE
3 indications
Trace cofactor mineral used in mineral supplements and parenteral nutrition
A12CX-MANGANESE
2 indications
Calcium channel blockers, dihydropyridine
C08CA11
2 indications
Over-the-counter botanical supplement, the resin of Pistacia lentiscus var. Chia (Chios mastic), cultivated on the island of Chios in Greece; marketed for functional dyspepsia and H. pylori
A02BX-MASTIC
3 indications
Antispasmodics (myotropic)
A03AA04
3 indications
Medium-chain fatty acids C8 (caprylic) and C10 (capric), extracted from coconut and palm kernel oil. Supplement. In clinical medicine MCT is used in enteral and parenteral nutrition in malabsorption syndrome, cystic fibrosis and ketogenic diet for drug-resistant epilepsy. AEMPS does not register it as a monoproduct medicine
A16AX-MCT
3 indications
Progestogen-only long-acting injectable contraceptive
G03AC06
2 indications
Other immunostimulants (local classification)
J05AX-CYCLOFERON
6 indications
Hypnotics. Melatonin receptor agonists
N05CH01
5 indications
Metabolic agents (local classification). Russian and Latvian development.
C01EB-MELDONIUM
3 indications
Herbal sedative, EMA HMPC traditional herbal medicinal product
N05CX-MELISSA
3 indications
NSAID, COX-2 preferential, oxicam derivative
M01AC06
1 indication
Non-competitive NMDA receptor antagonist
N06DX01
2 indications
Vitamins. γ-glutamyl carboxylase cofactor
B02BA-K2
3 indications
Fat-soluble vitamin K2 (MK-7 form)
B02BA01
3 indications
Opioid analgesic, phenylpiperidine class
N02AB02
1 indication
Locally acting intestinal aminosalicylate
A07EC02
2 indications
Analgesics and antipyretics. Pyrazolones
N02BB02
3 indications
Biguanides. Oral antihyperglycemic agents
A10BA02
5 indications
Synthetic opioid, full mu-receptor agonist
N07BC02
1 indication
Antimetabolites, folic acid analogues
L01BA01
4 indications
Active coenzyme form of vitamin B12
B03BA05
4 indications
Centrally-acting antiadrenergic agent
C02AB02
2 indications
Centrally acting psychostimulant
N06BA04
2 indications
Systemic glucocorticoid
H02AB04
1 indication
Dietary supplement. Organic sulphur compound, dimethyl sulfone. AEMPS does not register as a medicine; in Russia and Spain – dietary supplement
V06DX-MSM
3 indications
Antidotes (V03AB17). The drug has one FDA-approved indication – methaemoglobinaemia. Biohacker use is off-label.
V03AB17-METHYLENE-BLUE
4 indications
Prokinetic, dopamine D2 receptor antagonist
A03FA01
3 indications
Selective β1-adrenoceptor blockers
C07AB02
5 indications
Imidazole derivatives (antiprotozoal / antibacterial)
J01XD01
4 indications
Imidazole antifungal
D01AC02
1 indication
Antiprogestins, selective progesterone receptor modulators
G03XB01
2 indications
Other dermatologicals (topical); peripheral vasodilators (systemic)
D11AX01
2 indications
Selective β3-adrenoceptor agonist for overactive bladder
G04BD12
2 indications
Other antidepressants (NaSSA)
N06AX11
4 indications
Mixed natural tocopherols with predominance of gamma- and delta-forms (plus alpha- and beta-tocopherol), supplement, marketed as «full-spectrum vitamin E», separate from pure alpha-tocopherol
A11HA-MIXED-TOCOPHEROLS
2 indications
Combined live attenuated viral vaccine
J07BD52
1 indication
Reversible MAO-A inhibitor (RIMA)
N06AG02
2 indications
Trace cofactor of molybdenum-dependent enzymes, supplement and parenteral nutrition component
A12CX-MOLYBDENUM
1 indication
Inhaled, intranasal, and topical corticosteroid
R03BA07
2 indications
Intranasal corticosteroid
R01AD09
3 indications
Lauric acid derivative, supplement. No medicinal status in EU or Russia. AEMPS and AESAN do not register monolaurin as a medicine
A11JA-MONOLAURIN
3 indications
Leukotriene receptor antagonists
R03DC03
4 indications
Natural opium alkaloids
N02AA01
3 indications
Fourth-generation fluoroquinolone
J01MA14
3 indications
Plant source of L-DOPA. Used in Ayurveda for Parkinson disease; in the West – biohacking supplement
A11JA-MUCUNA
4 indications
Topical antibiotic
D06AX09
1 indication
Immunosuppressant, selective inosine monophosphate dehydrogenase inhibitor
L04AA06
3 indications
Inositol stereoisomer, supplement. Has evidence base in polycystic ovary syndrome (PCOS)
A11JA-MYO-INOSITOL
2 indications
Acetylated form of L-tyrosine, marketed nootropic supplement
A16AA-NALT
1 indication
Antidotes, opioid receptor antagonists
V03AB15
2 indications
NSAID, propionic acid derivative
M01AE02
1 indication
Triptan, selective 5HT1B/1D receptor agonist
N02CC02
1 indication
Serine protease isolated from fermented soy natto. Supplements market it as a «natural blood thinner», «protection against stroke and thrombosis», and a «natural warfarin alternative». Neither AEMPS nor EMA register it as a medicine; AESAN classifies it as a complemento alimenticio without therapeutic indication. FDA has issued no approval and warned manufacturers in 2022 about illegal claims of myocardial infarction and stroke prevention.
B01AX-NATTOKINASE
3 indications
Highly selective β1-blocker with endothelial nitric oxide release
C07AB12
3 indications
Water-soluble vitamin B3 (amide form)
A11HA01
3 indications
Dietary supplements, NAD+ precursors (local classification)
A11JA-NMN
4 indications
Dietary supplements, NAD+ precursors (local classification)
A11JA-NR
3 indications
Nicotine replacement therapy for tobacco dependence
N07BA01
2 indications
Lipid-modifying agent, nicotinic acid derivative; vitamin B3 in acid form
C04AC01
2 indications
Dihydropyridine calcium channel blocker
C08CA05
2 indications
Intestinal antimicrobial
A07AX03
3 indications
Antiinflammatory and antirheumatic agents, non-steroids. Other NSAIDs
M01AX17
3 indications
Tyrosine kinase inhibitors
L01EX09
2 indications
Organic nitrate
C01DA02
5 indications
Nootropics (local classification). Russian development.
N06BX-NOOPEPT
2 indications
Combined hormonal contraceptive, transdermal route
G03AA13
2 indications
Older-generation progestogen-only pill
G03AC01
2 indications
Second-generation fluoroquinolone
J01MA06
4 indications
Polyene antifungal antibiotic
A07AA02
1 indication
Atypical antipsychotic – thienobenzodiazepine
N05AH03
3 indications
Plant antioxidant, supplement. In EU – traditional herbal medicinal product (EMA HMPC monograph 2014)
A11JA-OLIVE-LEAF
4 indications
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA08
1 indication
Angiotensin II receptor blocker (ARB, sartan)
C09CA08
2 indications
Lipid-modifying agents. Omega-3 polyunsaturated fatty acids
C10AX06
4 indications
Essential polyunsaturated fatty acids
A11JA
3 indications
Monounsaturated fatty acids
A11JA
3 indications
Proton pump inhibitors
A02BC01
5 indications
5-HT3 serotonin receptor antagonist
A04AA01
3 indications
Peripherally acting antiobesity drug – intestinal lipase inhibitor
A08AB01
2 indications
Neuraminidase inhibitors
J05AH02
2 indications
Intestinal antispasmodic, quaternary ammonium compound
A03AB06
2 indications
Semi-synthetic opioid analgesic (μ-agonist)
N02AA05
2 indications
Fixed-dose combination: long-acting opioid analgesic plus peripheral opioid receptor antagonist
N02AA55
2 indications
Posterior pituitary hormones
H01BB02
3 indications
Atypical antipsychotic – active metabolite of risperidone
N05AX13
2 indications
Endogenous fatty-acid amide (aliamide); in Italy and Spain registered as a complemento alimenticio and «specialty food for medical purposes» for chronic neuropathic pain
N02BG-PEA
2 indications
Plant adaptogen, supplement. In EU – traditional herbal medicinal product (EMA HMPC); OTC tincture in Russia
A11JA-PANAX-GINSENG
5 indications
Digestives. Multienzyme preparations
A09AA02
5 indications
Proton pump inhibitors
A02BC02
4 indications
Water-soluble vitamin B5
A11HA31
3 indications
Anilides. Analgesics and antipyretics
N02BE01
5 indications
Symptomatic cold preparation: analgesic-antipyretic, H1-antihistamine, and sympathomimetic decongestant
R05X
2 indications
Selective serotonin reuptake inhibitor (SSRI)
N06AB05
5 indications
Herbal sedative, EMA HMPC traditional herbal medicinal product
N05CX-PASSIFLORA
3 indications
Fixed-dose combination: ACE inhibitor plus thiazide-like diuretic
C09BX01
1 indication
Anxiolytics. Benzodiazepine derivatives
N05BA
3 indications
Antidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B)
N06AF03
1 indication
Other anxiolytics (local classification)
N05BX-PHENIBUT
5 indications
Antiepileptics. Barbiturates
N03AA02
4 indications
Nootropics (local classification). Russian development.
N06BX-PHENYLPIRACETAM
2 indications
Antiepileptic, hydantoin derivative (sodium channel blocker)
N03AB02
1 indication
Phospholipid (soy- or bovine-derived) supplement, marketed for age-related memory decline and cognitive biohacking
N06BX-PS
2 indications
Structural macromineral of bone and ATP; pharmaceutical and parenteral forms are potassium, sodium and calcium phosphates
A12CX-PHOSPHORUS
2 indications
Vitamin K1, haemostatic, antidote for coumarin anticoagulant overdose
B02BA01
3 indications
Vitamin K1. Haemostatics. Antagonist of indirect anticoagulants
B02BA01
4 indications
Nootropics and vasoactive agents (local classification). Russian development.
N06BX-PICAMILON
3 indications
Atypical antipsychotic, selective 5-HT2A inverse agonist
N05AX17
1 indication
First-generation antipsychotic, diphenylbutylpiperidine derivative
N05AG01
1 indication
Thiazolidinedione (PPAR-γ agonist), oral antidiabetic
A10BG03
2 indications
Old «nootropics» (local classification)
N06BX-PIRACETAM
7 indications
Combination nootropic (local classification)
N06BX-FEZAM
4 indications
Antifibrotic agents
L04AX05
2 indications
Statin (HMG-CoA reductase inhibitor)
C10AA08
2 indications
Conjugate polysaccharide vaccine
J07AL02
1 indication
Immunomodulatory drug (IMiD)
L04AX06
1 indication
Second-generation systemic triazole antifungal
J02AC04
2 indications
Potassium salt with systemic alkalinising effect, used for kidney stone prevention and hypokalaemia
A12BA02
2 indications
Iodine therapy for thyroid function
H03CA01
4 indications
Non-ergot dopamine D2/D3 receptor agonist
N04BC05
3 indications
Statin (HMG-CoA reductase inhibitor)
C10AA03
2 indications
Glucocorticoids
H02AB06
7 indications
Short-to-medium acting systemic glucocorticoid
H02AB07
3 indications
Gabapentinoids (antiepileptics)
N03AX16
4 indications
Endogenous C21 steroid precursor; sold as a supplement on iHerb and Amazon; not registered as a drug in the EU
A14AA-PREGNENOLONE
4 indications
Probiotic microorganisms
A07FA-PROBIOTICS
10 indications
Progestogens — progesterone derivatives
G03DA04
5 indications
First-generation phenothiazine antihistamine, strongly sedating
R06AD02
2 indications
Muscarinic blocker with additional calcium channel blockade
G04BD06
3 indications
Bee product, supplement. Not registered as monomedicine in EU or AEMPS; OTC segment in Italy and Germany
A11JA-PROPOLIS
5 indications
Non-selective beta blocker
C07AA05
5 indications
Combined enzyme preparations, systemic enzyme therapy (local classification)
M01AX-WOBENZYM
3 indications
Soluble and insoluble fibre from seed husk. AEMPS registered Plantaben and Cenat as medicinal products for chronic constipation and maintenance of normal defecation. ACG 2014 and NICE NG61 IBS 2017 list psyllium as the primary soluble fibre
A06AC-PSYLLIUM
4 indications
Plant stilbene, supplement. Natural polyphenol from blueberries, grapes and red sandalwood. Often sold combined with nicotinamide riboside (NR) in longevity complexes
A11JA-PTEROSTILBENE
3 indications
Botanical supplement, pumpkin seed extract (Cucurbita pepo); EMA HMPC traditional-use herbal medicinal product for BPH symptoms and overactive bladder; sold on iHerb and Amazon for «prostate health» and women's «urinary comfort»
G04CX-PUMPKIN
3 indications
Plant product, supplement. In EU – traditional herbal medicinal product per EMA HMPC monograph; AEMPS does not register as monomedicine
A11JA-PUMPKIN-SEED-OIL
4 indications
Plant polyphenol complex, supplement. Standardised maritime pine bark extract with 65–75% oligomeric proanthocyanidins
A11JA-PYCNOGENOL
6 indications
Botanical supplement, bark extract of African plum (Prunus africana); EMA HMPC traditional-use herbal medicinal product for BPH symptoms; popular iHerb and Amazon «prostate health» category
G04CX-PYGEUM
2 indications
Vitamins. Coenzyme
A11HA02
5 indications
Dietary supplements, redox cofactors (local classification)
A11JA-PQQ
3 indications
Dietary supplements, flavonoids (local classification). Also registered in Russia as an angioprotective agent.
A11JA-QUERCETIN
3 indications
Atypical antipsychotics
N05AH04
4 indications
Class Ia antiarrhythmic (sodium channel blocker with intermediate kinetics)
C01BA01
1 indication
Proton pump inhibitor (PPI)
A02BC04
3 indications
Angiotensin-converting enzyme inhibitor (ACE-I)
C09AA05
3 indications
Antianginal – late sodium current inhibitor
C01EB18
2 indications
Selective irreversible monoamine oxidase B inhibitor
N04BD02
2 indications
Herbal source of isoflavones (food supplement under Spanish RD 1487/2009)
G03CX-RED-CLOVER
2 indications
Medicinal mushroom of traditional Chinese medicine, supplement. AEMPS does not register as medicine
A11JA-REISHI
5 indications
Meglitinide – short-acting oral insulin secretagogue
A10BX02
2 indications
Dietary supplements, plant polyphenols (local classification)
A11JA-RESVERATROL
5 indications
Fat-soluble vitamin A
A11CA01
3 indications
Plant adaptogen, supplement. In EU – traditional herbal medicinal product per EMA HMPC monograph
A11JA-RHODIOLA
4 indications
Water-soluble vitamin B2
A11HA04
2 indications
Antituberculous antibiotic
J04AB02
5 indications
Soluble guanylate cyclase (sGC) stimulator
C02KX05
1 indication
Nitrogen-containing bisphosphonate
M05BA07
2 indications
Atypical antipsychotic – dopamine and serotonin receptor antagonist
N05AX08
4 indications
HIV protease inhibitor / pharmacokinetic booster
J05AE03
1 indication
Direct oral anticoagulants (factor Xa inhibitors)
B01AF01
5 indications
Acetyl- and butyrylcholinesterase inhibitor
N06DA03
3 indications
Selective 5-HT1B/1D serotonin receptor agonist
N02CC04
3 indications
Selective phosphodiesterase-4 (PDE-4) inhibitor
R03DX07
2 indications
Non-ergot dopamine D2/D3 receptor agonist
N04BC04
3 indications
HMG-CoA reductase inhibitors (statins)
C10AA07
4 indications
Fixed-dose combination: statin plus intestinal cholesterol absorption inhibitor
C10BA06
1 indication
Bee product, secretion of pharyngeal glands of worker honeybees (Apis mellifera), supplement with high allergen risk
A11JA-ROYAL-JELLY
2 indications
Recombinant protein vaccine, stabilized prefusion F protein
J07BX05
2 indications
Second-generation antihistamine with additional PAF antagonism
R06AX28
3 indications
Methylation cofactor. In Italy and Germany – RX (Donamet, Samyr) for cholestatic liver injury and depression; in the US and Spain – supplement. AEMPS registers Donamet and Samyr (Abbvie/Abbott) for intrahepatic cholestasis
N06AX-SAMe
5 indications
Yeast probiotic. AEMPS registered Enterol (Biocodex) as a medicinal product for AAD, travellers diarrhoea and adjunct therapy for C. difficile
A07FA-SBOULARDII
4 indications
Angiotensin receptor-neprilysin inhibitor (ARNI)
C09DX04
2 indications
Herbal antidepressant supplement, standardised affron® and Safr'Inside® extracts
N06AX-SAFFRON
3 indications
Short-acting beta-2 adrenergic agonists (SABA)
R03AC02
7 indications
Long-acting selective β2-agonist (LABA, bronchodilator)
R03AC12
3 indications
Fixed-dose combination: long-acting beta-2 agonist (LABA) plus inhaled corticosteroid (ICS)
R03AK06
2 indications
Dietary supplements and phytotherapeutics, sabal palm fruit extracts (local classification)
A11JA-SAW-PALMETTO
2 indications
Plant adaptogen, supplement. In EU – EMA HMPC assessment 2024; OTC tincture in Russia
A11JA-SCHISANDRA
4 indications
Herbal preparation, sea buckthorn berries and seeds (Hippophae rhamnoides); in Russia sea buckthorn oil is a registered medicinal product for topical use
A11JA-SEA-BUCKTHORN
3 indications
Anxiolytics (local classification). Russian development.
N05BX-SELANK
2 indications
Selective irreversible MAO-B inhibitor
N04BD01
1 indication
Mineral supplements. Trace elements
A12CE-SELENIUM
5 indications
GLP-1 receptor agonists
A10BJ06
5 indications
Neuropeptides and nootropics (local classification). Russian development.
N06BX-SEMAX
3 indications
Selective serotonin reuptake inhibitors (SSRIs)
N06AB06
6 indications
Phosphodiesterase type 5 inhibitors (PDE5)
G04BE03
4 indications
Mineral in supplement form. Not registered as medicine in EU or AEMPS
A11JA-SILICA
3 indications
Highly selective α1A-adrenergic blocker
G04CA04
2 indications
Plant antioxidant from milk thistle fruits; IV silibinin is an antidote in Amanita phalloides poisoning
A05BA03
6 indications
Drugs for functional bowel disorders. Antifoaming agents
A03AX13
4 indications
HMG-CoA reductase inhibitors (statins)
C10AA01
3 indications
Fixed-dose combination: statin plus intestinal cholesterol absorption inhibitor
C10BA02
1 indication
Selective immunosuppressant, mTOR inhibitor
L04AA10
1 indication
Dipeptidyl peptidase-4 (DPP-4) inhibitor
A10BH01
2 indications
Fixed-dose combination: DPP-4 inhibitor plus biguanide
A10BD07
1 indication
Over-the-counter botanical supplement, the inner bark of Ulmus rubra (slippery elm, a North American tree); a mucilage demulcent with traditional use for irritation of the gastrointestinal and throat mucosa
A02BX-SLIPPERY-ELM
4 indications
Immunomodulators (local classification). Russian development.
L03AX-DERINAT
2 indications
Selective M3 muscarinic blocker for overactive bladder
G04BD08
3 indications
Antimuscarinic for overactive bladder
G04BD08
2 indications
Recombinant human growth hormone
H01AC01
2 indications
Non-selective beta blocker with class III antiarrhythmic activity
C07AA07
2 indications
Dietary supplements, polyamines (local classification)
A11JA-SPERMIDINE
3 indications
Potassium-sparing diuretics (mineralocorticoid receptor antagonists)
C03DA01
5 indications
Cyanobacterium (Arthrospira platensis / maxima), supplement, plant protein source, marketed as «detox» and «superfood»
A11JA-SPIRULINA
2 indications
Herbal antidepressant, EMA HMPC well-established use
N06AX25
3 indications
Botanical supplement, stinging nettle leaf (Urtica dioica folium); in the EU registered as a traditional-use herbal medicinal product (EMA HMPC) for mild rheumatic pain and as a diuretic; sold on iHerb for «blood detox» and immunity. NOTE: nettle root (Urtica dioica radix) is a different product, indicated for benign prostatic hyperplasia
M01AX-NETTLE-LEAF
2 indications
Botanical supplement, stinging nettle root (Urtica dioica radix); EMA HMPC traditional-use herbal medicinal product for BPH symptoms; sold on iHerb and Amazon for «prostate health». NOTE: nettle leaf (Urtica dioica folium) is a different product with a different profile (rheumatic pain, diuresis)
G04CX-NETTLE-ROOT
2 indications
Plant extract, supplement. In EU – traditional herbal medicinal product per EMA HMPC monograph 2010 for BPH symptoms; AEMPS does not register as monomedicine
A11JA-URTICA-ROOT
3 indications
Intestinal aminosalicylate and disease-modifying antirheumatic drug (DMARD)
A07EC01
3 indications
Plant isothiocyanate, supplement. Formed from glucoraphanin (Brassica oleracea) by myrosinase. Activator of the Nrf2-Keap1 pathway
A11JA-SULFORAPHANE
4 indications
Selective 5-HT1B/1D serotonin receptor agonist
N02CC01
3 indications
Multi-target tyrosine kinase inhibitor – VEGFR, PDGFR, c-KIT, FLT3, RET
L01EK02
2 indications
Calcineurin inhibitor (immunosuppressant)
L04AD02
1 indication
Phosphodiesterase type 5 (PDE-5) inhibitor
G04BE08
3 indications
Selective estrogen receptor modulator (SERM)
L02BA01
2 indications
Alpha-adrenergic blockers for prostatic disorders
G04CA02
3 indications
Opioid analgesic with dual mechanism
N02AX06
3 indications
Sulfur-containing amino acid, supplement and energy-drink ingredient. In Russia registered as a medicine (Dibicor) for T2DM and CHF
A16AA-TAURINE
4 indications
Bile acid, conjugate of ursodeoxycholic acid with taurine. RX medicine in Japan; in EU/US sold as supplement. AEMPS does not register it as a medicine. Not registered in Russia via GRLS
A05AA-TUDCA
2 indications
Combined inactivated bacterial vaccine (Td + acellular pertussis)
J07AJ52
2 indications
Angiotensin II receptor blocker (ARB)
C09CA07
1 indication
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA07
1 indication
Allylamine antifungal (systemic and topical)
D01BA02
3 indications
Methylxanthine
R03DA04
3 indications
Antithyroid preparations. Sulfur-containing imidazole derivatives
H03BB02
4 indications
Water-soluble vitamin B1
A11DA01
3 indications
Centrally acting muscle relaxant
M03BX05
2 indications
Synthetic steroid with estrogenic, progestogenic and weak androgenic activity
G03CX01
3 indications
Reversible P2Y12 receptor inhibitor
B01AC24
2 indications
Other antivirals (local classification)
J05AX-TILORONE
5 indications
Topical non-selective beta blocker for ophthalmic use
S01ED01
3 indications
Antiprotozoal and antibacterial, 5-nitroimidazole derivative
P01AB02
1 indication
Long-acting muscarinic antagonist for inhalation (LAMA)
R03BB04
5 indications
Blood glucose lowering drugs, GLP-1 and GIP receptor agonists
A10BJ09
3 indications
Natural vitamin E forms (4 isomers α, β, γ, δ)
A11HA-TOCOTRIENOLS
3 indications
Muscarinic receptor antagonist for overactive bladder
G04BD07
4 indications
Botanical supplement, Eurycoma longifolia root, traditional Malaysian and Indonesian medicine; sold on iHerb and Amazon as a «natural testosterone booster», adaptogen and aphrodisiac. NOTE: in 2016-2019 the FDA recalled tongkat ali products for lead contamination and adulteration with synthetic PDE-5 inhibitors
G03BB-TONGKAT-ALI
3 indications
Antiepileptic with multiple mechanisms
N03AX11
3 indications
Loop diuretic – sulfonamide derivative
C03CA04
3 indications
Other opioids
N02AX02
3 indications
Fixed-dose combination: weak opioid with SNRI activity plus non-opioid analgesic
N02AJ13
2 indications
Antifibrinolytics, amino acids
B02AA02
4 indications
Antidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B), amphetamine derivative
N06AF04
1 indication
Topical prostaglandin F2α analogue for ophthalmic use
S01EE04
3 indications
Serotonin antagonist and reuptake inhibitor (SARI) antidepressant
N06AX05
3 indications
Potassium-sparing diuretic, collecting duct sodium channel blocker
C03DB02
1 indication
Plant «testosterone booster» and aphrodisiac of Bulgarian folk medicine, supplement. AEMPS does not register as medicine
A11JA-TRIBULUS
3 indications
GI motility regulator, peripheral opioid receptor agonist
A03AA05
2 indications
Antibacterial, dihydrofolate reductase inhibitor
J01EA01
1 indication
Quaternary ammonium muscarinic blocker for overactive bladder
G04BD09
3 indications
Medicinal mushroom. In Japan PSK (Krestin) approved as chemotherapy adjuvant for gastric cancer since 1977. In EU and AEMPS not registered as medicine; sold as supplement
A11JA-TURKEY-TAIL
3 indications
Other cardiac preparations. Coenzyme Q10
C01EB-COQ10
5 indications
Other cardiac preparations; dietary supplements
C01EB09
4 indications
Selective progesterone receptor modulator (SPRM)
G03AD02
2 indications
Other antivirals
J05AX13
4 indications
Ellagitannin metabolite, supplement. Formed by gut microbiota from ellagitannins in pomegranates, walnuts and raspberries. Synthetic form Mitopure (Amazentis) is patented and sold in EU and US
A11JA-UROLITHIN-A
3 indications
Bile acid preparations
A05AA02
5 indications
Biologic – interleukin-12 and -23 inhibitor
L04AC05
4 indications
Antiviral – aciclovir prodrug
J05AB11
4 indications
Herbal sedative, EMA HMPC traditional herbal medicinal product
N05CM09
2 indications
Antiepileptics. Fatty acid derivatives
N03AG01
5 indications
Broad-spectrum antiepileptic, fatty acid derivative
N03AG01
1 indication
Angiotensin II receptor blockers (ARBs)
C09CA03
4 indications
Fixed-dose combination: angiotensin II receptor blocker plus thiazide diuretic
C09DA03
1 indication
Phosphodiesterase type 5 (PDE-5) inhibitor
G04BE09
2 indications
SNRI (serotonin-norepinephrine reuptake inhibitor)
N06AX16
1 indication
Non-dihydropyridine calcium channel blocker
C08DA01
5 indications
Dipeptidyl peptidase-4 (DPP-4) inhibitor
A10BH02
2 indications
Fixed-dose combination: DPP-4 inhibitor plus biguanide
A10BD08
2 indications
Vinca alkaloid, microtubule assembly inhibitor
L01CA02
1 indication
Psychostimulants and nootropics. Other psychostimulants and nootropics
N06BX18
4 indications
Other antivirals (local classification)
J05AX-INGAVIRIN
4 indications
Water-soluble B-vitamin; cofactor of methionine synthase and methylmalonyl-CoA mutase
B03BA-VITAMIN-B12
5 indications
Herbal preparation for PMS, supplement. In EU – traditional herbal medicinal product (EMA HMPC). AEMPS does not register as medicine
A11JA-VITEX
3 indications
Triazole derivatives, systemic antifungals
J02AC03
2 indications
Multimodal antidepressant
N06AX26
2 indications
Vitamin K antagonist anticoagulants
B01AA03
4 indications
Xanthophyll carotenoid, supplement marketed for retinal blue-light protection
A11JA-ZEAXANTHIN
2 indications
Mineral supplements. Trace elements
A12CB-ZINC
5 indications
Atypical antipsychotic – indole derivative
N05AE04
2 indications
Triptan, selective 5HT1B/1D receptor agonist
N02CC03
1 indication
Non-benzodiazepine hypnotic (Z-drug), imidazopyridine
N05CF02
2 indications
Antiepileptic with multiple mechanisms
N03AX15
2 indications
Other immunostimulants (synthetic peptides, local classification)
L03AX-THYMOGEN
3 indications