Evigrade

Monolaurin (glycerol monolaurate)

Lauric acid derivative, supplement. No medicinal status in EU or Russia. AEMPS and AESAN do not register monolaurin as a medicine

ATC code: A11JA-MONOLAURIN

Brand names – supplements: Inspired Nutrition Monolaurin, Ecological Formulas Monolaurin, Now Monolaurin, LauricidinSupplements are not tested in clinical trials and are not registered as medications.

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Cold sores (herpes labialis)

Not recommended

Monolaurin is a monoglyceride of lauric acid sold as a supplement for cold sores (herpes labialis), promoted for the antiviral activity it shows in lab settings. In people with cold sores it has not shown convincing benefit – there is no evidence base for this use. What actually helps during a flare are oral or topical antivirals such as aciclovir or valaciclovir, especially when started at the first signs. The substance itself is harmless in this role, but do not use it instead of treatment with proven benefit, or you may miss out on care that works.

ICD-10: B00.1 · ICD-11: 1F00.01

D

Herpes simplex

Not recommended

Monolaurin (lauric acid monoglyceride) is a supplement derived from coconut and palm oil. It is promoted as an antiviral, including for herpes simplex. No convincing benefit has been shown for this use: the supporting data come only from low-quality studies. For herpes simplex flare-ups, antiviral drugs such as aciclovir and valaciclovir do work. The substance is safe in this role, but do not use it in place of therapy with proven benefit, or you may miss out on treatment that helps.

ICD-10: B00 · ICD-11: 1F00.Z

D

Immune support and respiratory infection care

Not recommended

Monolaurin is a monoglyceride of lauric acid, sold as a supplement to support immunity and help with respiratory infections. There is no convincing evidence for this use: nothing reliably shows that monolaurin prevents colds or eases their course. For a respiratory infection, rest, fluids and time do the work, while flu vaccination and, when indicated, antivirals with proven benefit are what actually shorten or soften symptoms. Do not take monolaurin in place of treatment with proven benefit, since that can mean missing the care you need.

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Monolaurin is a monoester of glycerol and lauric acid (12-carbon). Naturally present in human breast milk and coconut oil in small amounts. In vitro it disintegrates the lipid membrane of some enveloped viruses (HSV-1, HSV-2, CMV, HIV, influenza) and gram-positive bacteria (S. aureus, including MRSA). The molecular human mechanism is not characterised. Oral bioavailability is low: monolaurin is rapidly hydrolysed by intestinal lipases to lauric acid and glycerol, after which lauric acid enters the general fatty acid pool. Intact monolaurin plasma concentrations in humans after oral intake have not been measured. All clinical effects extrapolated from in vitro models lack RCT confirmation in humans.

Safety

Contraindications

  • Coconut or coconut product allergy
  • Children under 12 (no dosing and safety data)
  • Severe lipid metabolism disorders (theoretical fatty acid profile influence)
  • Substitute for proven antiviral therapy in confirmed HSV, HIV, hepatitis C

Serious adverse effects

  • Allergic reactions in coconut-hypersensitive patients (rare)
  • Masking of HSV symptoms with delayed aciclovir start in primary episode
  • Delayed antiretroviral therapy in HIV-risk patients relying on «natural defence»

Common adverse effects

  • Nausea
  • Heartburn
  • Diarrhoea (at >3000 mg/day)
  • Flatulence
  • Stool disturbance

Pregnancy: can you take Monolaurin (glycerol monolaurate)?

No RCT data in pregnancy. Lauric acid is naturally present in breast milk (≈5–7% of total fat). At dietary coconut oil intake monolaurin is considered safe. High supplement doses 1800–3600 mg/day in pregnancy have not been studied – avoid.

Breastfeeding: can you take Monolaurin (glycerol monolaurate)?

Lauric acid and monoglycerides are physiological breast milk components. At dietary coconut oil intake milk transfer raises no concerns. High supplement doses in lactating women have not been studied.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

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Frequently asked

What is Monolaurin (glycerol monolaurate) used for?

Monolaurin (glycerol monolaurate) is evaluated for the following indications with varying evidence strength: Cold sores (herpes labialis) (evidence tier D), Herpes simplex (evidence tier D), Immune support and respiratory infection care (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Monolaurin (glycerol monolaurate)?

Common side effects of Monolaurin (glycerol monolaurate) (≥ 1 in 100): Nausea, Heartburn, Diarrhoea (at >3000 mg/day), Flatulence, Stool disturbance. See the Safety section for uncommon and serious reactions.

Is Monolaurin (glycerol monolaurate) safe during pregnancy?

No RCT data in pregnancy. Lauric acid is naturally present in breast milk (≈5–7% of total fat). At dietary coconut oil intake monolaurin is considered safe. High supplement doses 1800–3600 mg/day in pregnancy have not been studied – avoid.

Is Monolaurin (glycerol monolaurate) compatible with breastfeeding?

Lauric acid and monoglycerides are physiological breast milk components. At dietary coconut oil intake milk transfer raises no concerns. High supplement doses in lactating women have not been studied.

Who should not take Monolaurin (glycerol monolaurate)?

Monolaurin (glycerol monolaurate) is contraindicated in: Coconut or coconut product allergy; Children under 12 (no dosing and safety data); Severe lipid metabolism disorders (theoretical fatty acid profile influence); Substitute for proven antiviral therapy in confirmed HSV, HIV, hepatitis C. Full list in the Safety section.

Other drugs in this group

Mucuna pruriens (velvet bean), Myo-inositol, Nicotinamide, Nicotinamide riboside (NR), Pumpkin seed oil (Cucurbita pepo, Cucurbita maxima), Sulforaphane (isothiocyanate from broccoli sprouts), Ashwagandha (Withania somnifera), D-chiro-inositol