We break down medicines, supplements, and cosmetics by evidence – without marketing and without emotions.
LactApp entered insolvency proceedings in November 2025 after 8 years of work and 50,000 active users in Spain. It is a loss for the million-plus mothers who relied on it. Here is what Evigrade is doing to close the remaining gap: cross-category coverage (drugs + cosmetics + supplements), evidence base on every card, and a sustainable business model that does not depend on grants.
Short answer: retinoids, hydroquinone, oxybenzone, octocrylene and fragrance phthalates are avoided through the whole lactation. Niacinamide, azelaic acid 15–20%, bakuchiol, mineral SPF and most moisturizers are safe. We break down ingredient classes, postpartum melasma and acne strategy, and what to do about hair dye and antiperspirants.
A four-night routine of exfoliant, retinoid, and two recovery nights collected a billion views online. The idea is sound, but the actual evidence sits in the individual components, not the schedule itself. Where it works, where it's oversold, and who really benefits from the calendar.
Evidence-based reviews of medicines and drug classes: which indications have proven efficacy, which rest on weak trials, and what current guidelines advise.
A single glass of grapefruit juice can raise blood levels of certain medications 2–5 times and hold them there for up to 72 hours. At risk: statins, calcium channel blockers, post-transplant immunosuppressants, several targeted oncology drugs, some antiarrhythmics, and select psychotropics. Class-by-class breakdown sourced from international guidelines.
Paracetamol is safer on the stomach and kidneys but riskier on the liver; ibuprofen treats inflammation but raises GI risk, strains the kidneys, and conflicts with anticoagulants. The article covers: what to pick for fever, headache, dental, muscular, dysmenorrhea, and post-op pain; when to combine the two; who should avoid each; and what not to mix with either, based on NICE NG143/NG226, Cochrane, AAP, FDA, and EMA.
Short answer: progestin-only pills (Cerazette, desogestrel 75 mcg), IUDs (copper and Mirena), Nexplanon implant and condoms are compatible with breastfeeding from day one. Combined oral contraceptives are postponed for 6 weeks to 6 months. Plan B (LNG 1500) – compatible with no pause; EllaOne (ulipristal) needs 24-hour nursing pause.
Nutraceuticals, vitamins and supplements versus medicines: how evidence and regulation differ, and which supplements actually help in specific deficiencies.
Spain caps over-the-counter melatonin at 1.99 mg per dose. The US sells 5 and 10 mg bottles in any supermarket. Trials show low doses work as well as high ones, and sometimes better. Inside: the regulatory logic, the dose-response evidence and a sane way to use it.
Two servings of fatty fish per week reduce cardiovascular mortality. Fish oil capsules at the same dose in healthy adults do not (Cochrane 2020, 162,000 participants). A trial-by-trial breakdown and the narrow cases where capsules are still warranted.
Magnesium tops supplement sales, yet almost nobody asks whether it gets along with the medications already in the drawer. Five documented interactions and one simple rule: nearly all are solved with a clock, not by giving anything up.
Cosmetic ingredients, routines and protocols graded by evidence: working concentrations, skin-type limits and marketing claims without clinical support.
Short answer: retinoids, hydroquinone, oxybenzone, octocrylene and fragrance phthalates are avoided through the whole lactation. Niacinamide, azelaic acid 15–20%, bakuchiol, mineral SPF and most moisturizers are safe. We break down ingredient classes, postpartum melasma and acne strategy, and what to do about hair dye and antiperspirants.
A four-night routine of exfoliant, retinoid, and two recovery nights collected a billion views online. The idea is sound, but the actual evidence sits in the individual components, not the schedule itself. Where it works, where it's oversold, and who really benefits from the calendar.
Sunscreen filters fall into three generations. The modern ones cover the full spectrum and stay photostable. The older ones protect worse and bring extra risks. What to look for on the label is below.
How we grade evidence at Evigrade: the traffic-light hierarchy behind drug cards, our sources, and why one drug can score differently across indications.
LactApp entered insolvency proceedings in November 2025 after 8 years of work and 50,000 active users in Spain. It is a loss for the million-plus mothers who relied on it. Here is what Evigrade is doing to close the remaining gap: cross-category coverage (drugs + cosmetics + supplements), evidence base on every card, and a sustainable business model that does not depend on grants.
The difference between a supplement and a medicine lies in the regulatory framework, not the molecule. Clinical trials, GMP, batch control – all standard for medicines, largely absent for supplements. With specific numbers from JAMA, ConsumerLab, Cochrane, and independent melatonin and omega-3 testing.