Journal
We break down medicines, supplements, and cosmetics by evidence – without marketing and without emotions.
Featured
- Methodology
Continuing the mission: how Evigrade closes the gap in lactation tools
LactApp entered insolvency proceedings in November 2025 after 8 years of work and 50,000 active users in Spain. It is a loss for the million-plus mothers who relied on it. Here is what Evigrade is doing to close the remaining gap: cross-category coverage (drugs + cosmetics + supplements), evidence base on every card, and a sustainable business model that does not depend on grants.
- Cosmetics
Cosmetics during breastfeeding: what to avoid and what is safe
Short answer: retinoids, hydroquinone, oxybenzone, octocrylene and fragrance phthalates are avoided through the whole lactation. Niacinamide, azelaic acid 15–20%, bakuchiol, mineral SPF and most moisturizers are safe. We break down ingredient classes, postpartum melasma and acne strategy, and what to do about hair dye and antiperspirants.
- Cosmetics
Skin Cycling: What the Evidence Actually Says vs. What TikTok Sells
A four-night routine of exfoliant, retinoid, and two recovery nights collected a billion views online. The idea is sound, but the actual evidence sits in the individual components, not the schedule itself. Where it works, where it's oversold, and who really benefits from the calendar.
Medicines
All in this category →Evidence-based reviews of medicines and drug classes: what works and what is marketing.
- #drug-interactions#grapefruit#cyp3a4
Grapefruit juice and medications: what not to combine and why
A single glass of grapefruit juice can raise blood levels of certain medications 2–5 times and hold them there for up to 72 hours. At risk: statins, calcium channel blockers, post-transplant immunosuppressants, several targeted oncology drugs, some antiarrhythmics, and select psychotropics. Class-by-class breakdown sourced from international guidelines.
- #ibuprofen#paracetamol#nsaid
Ibuprofen vs. paracetamol: how they differ and when to pick which one
Paracetamol is safer on the stomach and kidneys but riskier on the liver; ibuprofen treats inflammation but raises GI risk, strains the kidneys, and conflicts with anticoagulants. The article covers: what to pick for fever, headache, dental, muscular, dysmenorrhea, and post-op pain; when to combine the two; who should avoid each; and what not to mix with either, based on NICE NG143/NG226, Cochrane, AAP, FDA, and EMA.
- #lactancia#anticoncepcion#cerazette
Contraception during breastfeeding: what works, what to postpone
Short answer: progestin-only pills (Cerazette, desogestrel 75 mcg), IUDs (copper and Mirena), Nexplanon implant and condoms are compatible with breastfeeding from day one. Combined oral contraceptives are postponed for 6 weeks to 6 months. Plan B (LNG 1500) – compatible with no pause; EllaOne (ulipristal) needs 24-hour nursing pause.
Supplements
All in this category →Nutraceuticals, vitamins, supplements vs medicines: differences in evidence and regulation.
- #melatonin#sleep#supplements
Melatonin and Spain's 1.99 mg cap: the low-dose paradox
Spain caps over-the-counter melatonin at 1.99 mg per dose. The US sells 5 and 10 mg bottles in any supermarket. Trials show low doses work as well as high ones, and sometimes better. Inside: the regulatory logic, the dose-response evidence and a sane way to use it.
- #omega-3#cardiology#supplements
Omega-3: why fish on your plate works and capsules often do not
Two servings of fatty fish per week reduce cardiovascular mortality. Fish oil capsules at the same dose in healthy adults do not (Cochrane 2020, 162,000 participants). A trial-by-trial breakdown and the narrow cases where capsules are still warranted.
Cosmetics
All in this category →Cosmetic ingredients, routines, protocols, and formats. The Evigrade traffic light in action.
- #lactancia#cosmetica#retinol
Cosmetics during breastfeeding: what to avoid and what is safe
Short answer: retinoids, hydroquinone, oxybenzone, octocrylene and fragrance phthalates are avoided through the whole lactation. Niacinamide, azelaic acid 15–20%, bakuchiol, mineral SPF and most moisturizers are safe. We break down ingredient classes, postpartum melasma and acne strategy, and what to do about hair dye and antiperspirants.
- #skin-cycling#retinol#exfoliation
Skin Cycling: What the Evidence Actually Says vs. What TikTok Sells
A four-night routine of exfoliant, retinoid, and two recovery nights collected a billion views online. The idea is sound, but the actual evidence sits in the individual components, not the schedule itself. Where it works, where it's oversold, and who really benefits from the calendar.
- #spf#sunscreen#filters
Legacy SPF filters: what to replace in 2026
UV filters split into three generations. Modern ones cover the full spectrum and stay photostable. Legacy ones underperform and carry extra risk. Here is what to look for.
Methodology
All in this category →How we grade evidence, how to read drug cards, how supplements differ from medicines.
- #lactancia#lactapp#mission
Continuing the mission: how Evigrade closes the gap in lactation tools
LactApp entered insolvency proceedings in November 2025 after 8 years of work and 50,000 active users in Spain. It is a loss for the million-plus mothers who relied on it. Here is what Evigrade is doing to close the remaining gap: cross-category coverage (drugs + cosmetics + supplements), evidence base on every card, and a sustainable business model that does not depend on grants.
- #supplements#evidence-based#drug-regulation
Supplements vs medicines: why even working molecules belong in a drug form
The difference between a supplement and a medicine lies in the regulatory framework, not the molecule. Clinical trials, GMP, batch control – all standard for medicines, largely absent for supplements. With specific numbers from JAMA, ConsumerLab, Cochrane, and independent melatonin and omega-3 testing.