Methodology and editorial principles
How Evigrade evaluates drugs and cosmetic ingredients. Methodology, legal stance, right of reply.
What Evigrade publishes
Evigrade publishes analytical reviews and editorial opinions based on public international clinical guidelines, randomized controlled trials, and meta-analyses.
How tiers are assigned
Evidence tiers (A, B, C, D, F) are assigned by the editorial board following a public reproducible methodology and are re-evaluated as new data emerges.
- Tier A – confirmed by ≥2 independent RCTs with clinical endpoints.
- Tier B – one RCT or several controlled studies with limitations.
- Tier C – conflicting data, in vitro or open-label studies.
- Tier D – very weak or conflicting evidence base.
- Tier F – no evidence of efficacy, or proven inefficacy.
The methodology follows the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) and the Oxford Centre for Evidence-Based Medicine Levels of Evidence.
Legal nature of the content
The content presents editorial opinions, not statements of fact, and does not aim to advertise or counter-advertise specific manufacturers. Ratings apply to the international nonproprietary drug name, not to any particular brand.
Evaluative opinions based on public sources are not subject to factual refutation. The editorial evidence rating reflects the editorial board's opinion grounded in publicly available guidelines and studies; it does not contain statements of fact susceptible to verification.
Right of reply
Manufacturers and rights holders may submit a reasoned reply to editorial@evigrade.com. The editorial team publishes the reply unedited within 14 business days.
A reply must include references to published scientific data. The editorial team reserves the right to append its own commentary without modifying the text of the reply itself.
Corrections and re-evaluation
The editorial team re-evaluates tiers as new randomized controlled trials, meta-analyses, or updated clinical guidelines from international specialist associations appear. Each card displays the date of the last review.
What the tier rates
Ratings apply to the international nonproprietary drug name and a specific indication, not to brands. The same INN receives different tiers for different indications. A tier F for one indication does not imply inefficacy for other indications.
Conflicts of interest
Evigrade is an independent encyclopedia. The editorial team has no direct commercial ties to drug or cosmetics manufacturers. Tier ratings do not depend on marketplace availability, manufacturer advertising budgets, or partnership requests.
Medical disclaimer
This content does not replace consultation with a licensed physician.
Contact the editorial team
General inquiries: editorial@evigrade.com