Methodology
How we grade evidence at Evigrade: the traffic-light hierarchy behind drug cards, our sources, and why one drug can score differently across indications
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About this section
This section explains how Evigrade builds its evidence assessments. The drug card traffic-light system relies on a research hierarchy: systematic reviews and meta-analyses (green tier), high-quality RCTs (green), RCTs with limitations (yellow), observational cohorts (yellow), and case series and in vitro studies (red). Regulatory sources are distinguished: international society guidelines (ESC, ESH, EASL, AASLD, ESMO) and Russian Ministry of Health clinical recommendations. Sources are cited by DOI or PubMed link for every statement. This section is for readers who want to understand exactly what the traffic light rests on and why the same drug can hold different ratings across different indications.