Other immunostimulants (synthetic peptides, local classification)
Updated · Methodology
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
Not recommended
For chronic tonsillitis and pharyngitis, Thymogen is absent from -HNS and ESPO ENT guidelines. Evidence-based management: hygiene, antibiotic therapy for purulent flares on indication, and tonsillectomy in confirmed recurrences by Paradise criteria.
ICD-10: J31.2 · ICD-11: CA09.2
Not recommended
Thymogen is marketed as an immunoregulator for frequently ill adults and children as injection solution, spray, and ointment. International clinical guidelines (, , ) do not include the drug; the , , and AEMPS have not approved it. No independent international clinical studies exist. If Thymogen was recommended, consider seeking a second opinion.
Not recommended
Alpha-Glutamyl-L-tryptophan is a synthetic dipeptide marketed as an immunomodulator to prevent recurrent respiratory infections. For this use the benefit has not been demonstrated: the positive data come only from low-quality studies, and international guidelines do not include it. It should not be expected to cut the number of episodes. What does lower the rate of respiratory infections: vaccination (influenza, pneumococcus where indicated), enough sleep, hand washing and not smoking.
Sources
ICD-10: Z29.9
Synthetic dipeptide – a structural fragment of thymopoietin. The manufacturer claims regulation of T-cell immunity. The molecule is not described as a therapeutic agent in international pharmacological literature. Produced and used only in Russia by Cytomed.
Contraindicated in pregnancy per the manufacturer label.
Contraindicated during breastfeeding per the manufacturer label.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
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α-Glutamyl-L-tryptophan is evaluated for the following indications with varying evidence strength: Chronic tonsillitis and pharyngitis (evidence tier D), Immune support and respiratory infection care (evidence tier D), Prevention of recurrent respiratory infections (evidence tier D). See the full indication matrix with dosing and citations above on this page.
Common side effects of α-Glutamyl-L-tryptophan (≥ 1 in 100): Allergic reactions (rare per label), Local injection-site reactions. See the Safety section for uncommon and serious reactions.
Contraindicated in pregnancy per the manufacturer label.
Contraindicated during breastfeeding per the manufacturer label.
α-Glutamyl-L-tryptophan is contraindicated in: Pregnancy; Breastfeeding; Age under 6 months (nasal) or under 1 year (injection); Hypersensitivity. Full list in the Safety section.
Interferon α-2b in suppositories, Alloferon (Allokin-alfa), Cat's claw, Sodium deoxyribonucleate (Derinat), Aminodihydrophthalazinedione sodium, Bacterial lysates OM-85, Echinacea purpurea (juice/extract), Glucosaminyl muramyl dipeptide