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ESRU

Sodium deoxyribonucleate (Derinat)

Immunomodulators (local classification). Russian development.

ATC code: L03AX-DERINAT

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Common cold

Not recommended

Sodium deoxyribonucleate (Derinat) is marketed as an immunomodulator for treating and preventing acute respiratory viral infections. No convincing benefit has been shown for this use: there is no solid evidence base for it in respiratory viral infections. These infections usually clear on their own within a few days, and what actually helps is supportive care – rest, fluids, and symptom relief when needed. The substance is harmless in this role, but it should not replace an approach with proven benefit, since that risks missing the treatment a person needs.

Sources

  1. AEMPS: Ficha técnica de Desoxirribonucleato sódico (Derinat) (2024)
  2. Cochrane: Echinacea for preventing and treating the common cold (2014)

ICD-10: J00 · ICD-11: CA00

F

Immune support and respiratory infection care

Not recommended

Derinat is marketed in Russia as an immunomodulator for frequently ill children and adults, available as drops, spray, and injection. International clinical guidelines (, , , ) do not include the drug; the , , and AEMPS have not approved it. No independent international clinical studies exist. If Derinat was recommended, consider seeking a second opinion.

Sources

  1. AEMPS: Ficha técnica de Desoxirribonucleato sódico (Derinat) (2024)
  2. Cochrane (Hemila and Chalker): Vitamin C for preventing and treating the common cold (2013)
How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Derinat is a preparation of sodium salt of DNA extracted from sturgeon milt. The manufacturer claims immunomodulatory and reparative action. Developed and sold by Tekhnomedservis. Not present in international circulation. Independent RCTs with URI, influenza, or other infection incidence endpoints do not exist.

Safety

Contraindications

  • Hypersensitivity

Serious adverse effects

  • Independent data on serious adverse events are unavailable

Common adverse effects

  • Nasal mucosa irritation
  • Transient burning with topical use
  • Allergic reactions (rare)

Pregnancy: can you take Sodium deoxyribonucleate (Derinat)?

The manufacturer permits use in pregnancy when indicated; international validation is lacking.

Breastfeeding: can you take Sodium deoxyribonucleate (Derinat)?

The manufacturer permits use during breastfeeding.

Calculate RID

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

Practical notes

Russian practice note

Derinat is supplied as 0.25% nasal drops, spray, topical solution, and 1.5% injection. Registered only in Russia and the CIS. Retail price: nasal drops 300–500 ₽, injection 1500–2500 ₽ per pack. The drug is not indexed in international literature as a clinically meaningful agent. Foreign biohackers do not use it.

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Frequently asked

What is Sodium deoxyribonucleate (Derinat) used for?

Sodium deoxyribonucleate (Derinat) is evaluated for the following indications with varying evidence strength: Common cold (evidence tier D), Immune support and respiratory infection care (evidence tier F). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Sodium deoxyribonucleate (Derinat)?

Common side effects of Sodium deoxyribonucleate (Derinat) (≥ 1 in 100): Nasal mucosa irritation, Transient burning with topical use, Allergic reactions (rare). See the Safety section for uncommon and serious reactions.

Is Sodium deoxyribonucleate (Derinat) safe during pregnancy?

The manufacturer permits use in pregnancy when indicated; international validation is lacking.

Is Sodium deoxyribonucleate (Derinat) compatible with breastfeeding?

The manufacturer permits use during breastfeeding.

Who should not take Sodium deoxyribonucleate (Derinat)?

Sodium deoxyribonucleate (Derinat) is contraindicated in: Hypersensitivity. Full list in the Safety section.

Other drugs in this group

Echinacea purpurea (juice/extract), Aminodihydrophthalazinedione sodium, Glucosaminyl muramyl dipeptide, Bacterial lysates OM-85, α-Glutamyl-L-tryptophan, Alloferon (Allokin-alfa), Azoximer bromide, Interferon α-2b in suppositories