Immunomodulators, antivirals (local classification). Russian development.
ATC code: L03AX-ALLOKIN (Allokin-alfa (synthetic oligopeptide) – local code)
Allokin-alfa is a synthetic oligopeptide, analogue of a cytokine inducer isolated from Calliphora vicina larvae. The manufacturer claims NK cell activation and endogenous interferon induction. Developed in Russia and registered for HSV and HPV infection in adults. , EACS, , and guidelines do not list the drug. Independent international RCTs are unavailable.
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
Not recommended
For recurrent HSV-1 and HSV-2, allokin-alfa in Russia is indicated for short courses of subcutaneous injections. , BASHH, and guidelines do not list the drug. Evidence-based antiherpetics are nucleoside analogues , , and , with efficacy confirmed in large RCTs on episode duration and recurrence frequency endpoints.
Not recommended
Allokin-alpha is used off-label in Russia as an immunomodulator for frequently ill people and in HPV infection. International clinical guidelines (, , CDC, ) do not include the drug; the , , and AEMPS have not approved it. No independent international clinical studies exist. If allokin-alpha was recommended, consider seeking a second opinion.
Opens the checker prefilled with this drug. Pick the second one from your regimen.
Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
Alloferon (Allokin-alfa) is evaluated for the following indications with varying evidence strength: Immune support and respiratory infection care (evidence tier F), Herpes simplex (evidence tier F). See the full indication matrix with dosing and citations above on this page.
Common side effects of Alloferon (Allokin-alfa) (≥ 1 in 100): Local injection site reactions, Transient fever, Headache, Weakness, malaise. See the Safety section for uncommon and serious reactions.
FDA category N. Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
Alloferon (Allokin-alfa) is contraindicated in: Pregnancy and breastfeeding; Age under 18; Autoimmune disease; Hypersensitivity. Full list in the Safety section.