Evigrade

Quercetin

Dietary supplements, flavonoids (local classification). Also registered in Russia as an angioprotective agent.

ATC code: A11JA-QUERCETIN

Brand names: Solgar Quercetin Complex, Quercetin Now Foods, Thorne Quercetin Phytosome

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Allergic rhinitis

Not recommended

Quercetin is a plant flavonoid sold as an "anti-allergy" supplement and promoted for allergic rhinitis to ease a runny nose and sneezing. Convincing benefit for this use has not been shown, and there is no solid evidence base behind it. Allergic rhinitis responds to proven options: intranasal corticosteroids and antihistamines, and in some cases allergen-specific immunotherapy. Do not take quercetin instead of this treatment, or you risk missing care with proven benefit.

ICD-10: J30.9 · ICD-11: CA08.0

D

Anti-aging and longevity

Not recommended

Quercetin is a plant flavonoid found in onions, apples and capers, marketed in supplements as an anti-aging and longevity aid, sometimes paired with other so-called senolytics. There is no convincing human evidence that it slows aging, rejuvenates skin or extends lifespan. The compound itself is well tolerated at usual supplement doses. For healthy aging, the approaches that hold up are the proven ones: sleep, physical activity, diet, not smoking and sun protection.

D

Immune support and respiratory infection care

Not recommended

Quercetin is a plant flavonoid found in onions, apples and capers, sold as a supplement for immunity and for preventing colds and respiratory infections. For this use there is no convincing benefit: the data come from small, low-quality trials. For an acute respiratory infection, rest, fluids and symptom relief help, and prevention rests on flu vaccination and hand hygiene. The compound itself is safe at typical dietary and supplement amounts.

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Quercetin is a flavonoid found in onions, apples, capers, citrus, and tea. Cellular models describe antioxidant, anti-inflammatory, and senolytic activity (selective senescent cell clearance when combined with dasatinib). Oral bioavailability of pure quercetin is low. Large RCTs in humans with lifespan or clinical outcome endpoints are unavailable.

Safety

Contraindications

  • Pregnancy and breastfeeding
  • Age under 12
  • Severe renal impairment
  • Hypersensitivity
  • Concurrent warfarin, ciclosporin, tacrolimus

Serious adverse effects

  • Acute renal failure with high-dose IV administration (historical cases)

Common adverse effects

  • GI discomfort
  • Headache
  • Extremity tingling (at doses over 1 g/day)

Pregnancy: can you take Quercetin?

Use in pregnancy has not been studied; supplement is not recommended.

Breastfeeding: can you take Quercetin?

Use during breastfeeding has not been studied; supplement is not recommended.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

Practical notes

Russian practice note

Quercetin in Russia is registered as a medicinal product (Quercetin Evalar, granules for solution) with angioprotective indications, and as a dietary supplement in combinations. Marketing doses are 500–1000 mg/day, retail 600–2500 ₽/month. Bioavailability of pure quercetin is low (around 2%); manufacturers often use phytosomal forms or combinations with bromelain and vitamin C. The compound inhibits CYP3A4 and CYP2C9 at high doses, potentially clinically relevant with ciclosporin, warfarin, and tacrolimus.

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Frequently asked

What is Quercetin used for?

Quercetin is evaluated for the following indications with varying evidence strength: Anti-aging and longevity (evidence tier D), Allergic rhinitis (evidence tier D), Immune support and respiratory infection care (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Quercetin?

Common side effects of Quercetin (≥ 1 in 100): GI discomfort, Headache, Extremity tingling (at doses over 1 g/day). See the Safety section for uncommon and serious reactions.

Is Quercetin safe during pregnancy?

Use in pregnancy has not been studied; supplement is not recommended.

Is Quercetin compatible with breastfeeding?

Use during breastfeeding has not been studied; supplement is not recommended.

Who should not take Quercetin?

Quercetin is contraindicated in: Pregnancy and breastfeeding; Age under 12; Severe renal impairment; Hypersensitivity; Concurrent warfarin, ciclosporin, tacrolimus. Full list in the Safety section.

Official sources

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Other drugs in this group

Reishi (Ganoderma lucidum, lingzhi), Resveratrol, Retinol, Rhodiola rosea (golden root), Tocotrienols, Beta-carotene, Diindolylmethane (DIM), Myo-inositol