What is Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) used for?

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is evaluated for the following indications with varying evidence strength: Generalized anxiety disorder (evidence tier D), Stress and anxiety (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)?

Common side effects of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) (≥ 1 in 100): Nasal mucosa irritation, Allergic reactions (rare per label). See the Safety section for uncommon and serious reactions.

Is Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) safe during pregnancy?

FDA category N. Contraindicated in pregnancy per label.

Is Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) compatible with breastfeeding?

Contraindicated during breastfeeding per label.

Who should not take Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)?

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is contraindicated in: Pregnancy and breastfeeding; Age under 18; Hypersensitivity. Full list in the Safety section.

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

Anxiolytics (local classification). Russian development.

ATC code: N05BX-SELANK (Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) – local code)

Mechanism of action

Selank is a synthetic heptapeptide analogue of the endogenous immunomodulatory peptide tuftsin. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences with the Zakusov Research Institute of Pharmacology. The manufacturer claims anxiolytic effect via GABAergic and monoaminergic modulation. Independent international RCTs do not exist. The drug is absent from international anxiety disorder guidelines.

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

Generalized anxiety disorder

Not recommended

Selank is a synthetic peptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) marketed as a calming agent, including for generalized anxiety disorder. No convincing benefit for this use has been shown: international guidelines do not mention it, and high-quality RCTs are missing. For generalized anxiety disorder, the approaches with proven benefit are cognitive behavioral therapy and medicines from the SSRI and SNRI classes. Selank appears harmless in this role, but do not use it instead of treatment with proven benefit, since that can mean missing care that actually works.

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)

Mechanism of action

Marketing claims without evidence base

Generalized anxiety disorder

Stress and anxiety

Practical notes

Russian practice note

Check interaction with another drug

Safety

Contraindications

Serious adverse effects

Common adverse effects

PregnancyFDA N

Breastfeeding

Frequently asked