Calcium D-glucarate

Calcium D-glucarate is a salt of glucaric acid, sold as a "detox" supplement and promoted for breast cancer prevention through its effect on estrogen metabolism. The supplement has not shown convincing benefit for this use: there are no quality human studies that prove a lower breast cancer risk. What does lower risk is not smoking, keeping a healthy weight, limiting alcohol, age-appropriate screening, and discussing personal risk factors with a doctor. Do not take this supplement instead of approaches with proven benefit, since that can mean missing prevention or treatment that works

Calcium D-glucarate is sold as a supplement for so-called estrogen detox, on the idea that it slows the gut enzyme beta-glucuronidase and speeds estrogen clearance. For this use there is no solid evidence that it changes hormone levels or affects health. If you are worried about estrogen excess or related symptoms, a gynecologist or endocrinologist can look into the cause, which a supplement cannot do. The substance itself is well tolerated at usual doses.