Evigrade

Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)

Homeopathic medicines

ATC code: V03AX-ANAFERON(Anti-IFN-γ antibodies in homeopathic dilutions (local code))

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Common cold

Not recommended

Anaferon contains antibodies to human gamma interferon in homeopathic dilutions, and it is marketed for treating and preventing acute respiratory viral infections. A clear benefit for this use has not been shown: there is no reliable evidence behind this application. For a common viral respiratory illness, rest, fluids, fever reducers when needed, and time tend to help, and most people recover within a few days. Do not use this product in place of treatment with proven benefit, since that risks missing the care you actually need.

ICD-10: J00 · ICD-11: CA00

D

Herpes simplex

Not recommended

Anaferon contains antibodies to human gamma-interferon in ultra-low (homeopathic) dilutions and is promoted for treating and preventing viral infections, including herpes simplex. There is no convincing evidence that it helps with herpes simplex, and the evidence base for this use is missing. What actually works against herpes are antiviral medicines such as aciclovir or valaciclovir, prescribed by a doctor. Anaferon should not be used in place of treatment with proven benefit, since that can mean missing the care you need.

ICD-10: B00 · ICD-11: 1F00.Z

D

Immune support and respiratory infection care

Not recommended

Anaferon is a tablet containing antibodies to human gamma-interferon at homeopathic dilutions, marketed to support immunity and help with colds and flu. Studies have not shown convincing benefit for this use: international guidelines and good-quality RCTs do not list it as an agent with proven effect. Colds ease with rest, fluids and symptom relief; for influenza in at-risk patients a doctor may prescribe oseltamivir. Do not take it in place of treatment with proven benefit.

D

Influenza

Not recommended

Anaferon contains antibodies to human gamma interferon in homeopathic dilutions and is promoted to treat and prevent influenza. The drug has not shown convincing benefit for influenza: there is no solid evidence base for this use. What does help against flu is the approach backed by data – antivirals such as oseltamivir given early to people at risk, rest, fluids, and fever reducers as needed. Anaferon is harmless in this role, but do not take it instead of treatment with proven benefit, since that can mean missing the care you need

ICD-10: J10-J11 · ICD-11: 1E32

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

The manufacturer claims the use of high dilutions (C12, C30, C50) of affinity-purified antibodies against human interferon-gamma. At these dilutions the number of active molecules approaches or reaches zero (Avogadro's number), making the proposed mechanism of action pharmacologically implausible. Homeopathic products are methodologically incompatible with evidence-based medicine.

Safety

Contraindications

  • Lactase deficiency, galactose intolerance, glucose-galactose malabsorption
  • Age under 1 month (for pediatric formulation)
  • Hypersensitivity

Serious adverse effects

  • No independent data on serious adverse events

Common adverse effects

  • Per manufacturer label — allergic reactions

Pregnancy: can you take Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)?

Safety data during pregnancy are limited; international sources provide no recommendations.

Breastfeeding: can you take Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)?

Anaferon contains release-active (ultra-low) concentrations of antibodies to gamma-interferon, registered in Russia as a homeopathic product. Systematic reviews do not confirm efficacy; the proposed mechanism of action as a medicinal substance lacks supporting evidence. There are no human milk transfer data. Not registered in Spain; use during breastfeeding is not supported.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

Practical notes

Russian practice note

Anaferon and its variants are registered and produced in Russia; they are not available internationally. They belong to the homeopathic category, officially listed in the . A critical review of the homeopathic class is available in the Australia reports and the official position of the European Academies Science Advisory Council () from 2017.

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Frequently asked

What is Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) used for?

Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) is evaluated for the following indications with varying evidence strength: Herpes simplex (evidence tier D), Common cold (evidence tier D), Influenza (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)?

Common side effects of Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) (≥ 1 in 100): Per manufacturer label — allergic reactions. See the Safety section for uncommon and serious reactions.

Is Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) safe during pregnancy?

Safety data during pregnancy are limited; international sources provide no recommendations.

Is Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) compatible with breastfeeding?

Anaferon contains release-active (ultra-low) concentrations of antibodies to gamma-interferon, registered in Russia as a homeopathic product. Systematic reviews do not confirm efficacy; the proposed mechanism of action as a medicinal substance lacks supporting evidence. There are no human milk transfer data. Not registered in Spain; use during breastfeeding is not supported.

Who should not take Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)?

Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions) is contraindicated in: Lactase deficiency, galactose intolerance, glucose-galactose malabsorption; Age under 1 month (for pediatric formulation); Hypersensitivity. Full list in the Safety section.

Official sources

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Other drugs in this group

Cerebrolysin (porcine brain peptides), Cobicistat, Deferasirox, Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions), Ethylmethylhydroxypyridine succinate, Anas Barbariae Hepatis et Cordis Extractum (homeopathic), Methylthioninium chloride (methylene blue), Naloxone