Evigrade

Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions)

Homeopathic preparation marketed as an immunomodulator (local classification)

ATC code: V03AX-ERGOFERON(Ergoferon (homeopathic antibody dilutions) – local code)

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Common cold

Not recommended

Ergoferon combines antibodies to gamma-interferon, CD4, and histamine in homeopathic dilutions. The manufacturer markets it as an antiviral and immune-modulating remedy for acute respiratory viral infection. No convincing benefit has been shown for this use, and there is no quality evidence base behind it for the common cold or flu. For these infections, supportive care usually helps – rest, fluids, and symptomatic relief for fever and congestion; for influenza, a doctor may prescribe agents with proven antiviral activity when indicated. The substance is harmless in this role, but do not take it instead of treatment with proven benefit, so you do not miss the care you need.

ICD-10: J00 · ICD-11: CA00

D

Herpes simplex

Not recommended

Ergoferon combines antibodies to gamma-interferon, CD4 and histamine in ultra-low (homeopathic) dilutions, and is marketed as an antiviral and immune-modulating remedy, including for cold sores and other forms of herpes simplex. No convincing benefit for herpes simplex has been shown for it: there is no quality evidence base for this use. Herpes simplex responds to antiviral drugs of the aciclovir group (aciclovir, valaciclovir) prescribed by a doctor, and the earlier the course starts, the clearer the effect. Ergoferon is harmless in this role, but you should not use it instead of treatment with proven benefit, since that can mean losing time and the therapy you actually need.

ICD-10: B00 · ICD-11: 1F00.Z

D

Immune support and respiratory infection care

Not recommended

Ergoferon contains antibodies to gamma-interferon, CD4 and histamine in homeopathic dilutions, and it is marketed to support immunity and ease the common cold. Convincing benefit for this use has not been shown: there is no evidence base confirming any effect on the course of a cold or flu. For acute respiratory infections, rest, fluids and fever reducers when needed help, and in flu at-risk groups a clinician may prescribe antivirals with proven efficacy. Do not use Ergoferon in place of treatment with proven benefit, since that risks missing the care you actually need.

D

Influenza

Not recommended

Ergoferon contains antibodies to gamma interferon, CD4, and histamine in homeopathic dilutions, and it is marketed as an antiviral for influenza. Studies have not shown a convincing benefit for influenza, and there is no evidence base for this use. For influenza, antivirals with proven efficacy (such as oseltamivir) help when a doctor prescribes them, while healthy adults usually recover with rest, fluids, and fever reducers as needed. Do not take Ergoferon in place of treatment with proven benefit, since that can mean missing the care you need.

ICD-10: J10-J11 · ICD-11: 1E32

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

The manufacturer claims «activated-potentiated forms» of antibodies to γ-interferon, the CD4 receptor, and histamine. The preparation is homeopathic: dilutions exceed Avogadro's number, with less than one molecule of active substance per dose. Such dilutions lack biological plausibility under standard pharmacology. Developed and sold by Materia Medica Holding (Russia); chief – O.I. Epshtein.

Safety

Contraindications

  • Age under 6 months
  • Hypersensitivity
  • Lactose intolerance

Serious adverse effects

  • Independent data on serious adverse events are unavailable

Common adverse effects

  • Allergic reactions (rare per label)

Pregnancy: can you take Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions)?

Pregnancy and breastfeeding use is not studied per the label; the manufacturer does not recommend.

Breastfeeding: can you take Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions)?

The manufacturer does not recommend use during breastfeeding.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

Practical notes

Russian practice note

Ergoferon is produced and sold by Materia Medica Holding in Russia and the CIS. Not registered internationally. Belongs to the Anaferon, Tenoten, and Impaza family – all based on «release-activated» homeopathic antibody dilutions. , , and MHRA have not approved this line of products. Serious adverse events in homeopathy are rare only because there is essentially no active substance per dose.

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Frequently asked

What is Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) used for?

Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) is evaluated for the following indications with varying evidence strength: Influenza (evidence tier D), Common cold (evidence tier D), Herpes simplex (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions)?

Common side effects of Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) (≥ 1 in 100): Allergic reactions (rare per label). See the Safety section for uncommon and serious reactions.

Is Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) safe during pregnancy?

Pregnancy and breastfeeding use is not studied per the label; the manufacturer does not recommend.

Is Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) compatible with breastfeeding?

The manufacturer does not recommend use during breastfeeding.

Who should not take Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions)?

Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions) is contraindicated in: Age under 6 months; Hypersensitivity; Lactose intolerance. Full list in the Safety section.

Other drugs in this group

Methylthioninium chloride (methylene blue), Ethylmethylhydroxypyridine succinate, Naloxone, Anas Barbariae Hepatis et Cordis Extractum (homeopathic), Deproteinized hemoderivative from calf blood, Cerebrolysin (porcine brain peptides), Antibodies to S-100 brain-specific protein (homeopathic), Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions)