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Antibodies to S-100 brain-specific protein (homeopathic)

Homeopathic products (local classification)

ATC code: V03AX-TENOTEN(Tenoten (homeopathic, local code))

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

ADHD

Not recommended

Antibodies to brain-specific protein S-100, in homeopathic dilution, are marketed as a remedy for attention deficit hyperactivity disorder (ADHD) in children and adults. This product has not shown meaningful benefit in ADHD, and there is no reliable evidence for this use. ADHD responds to approaches with proven effect: behavioral therapy, support from teachers and psychologists, and, when needed, medication selected by a physician. Do not use this product in place of treatment with proven benefit, since that can cost time and access to real help.

Sources

  1. Cochrane Database Syst Rev: Homeopathy for attention deficit/hyperactivity disorder or hyperkinetic disorder. (2007)
  2. J Clin Psychiatry: Homeopathic treatments in psychiatry: a systematic review of randomized placebo-controlled studies. (2011)

ICD-10: F90.0 · ICD-11: 6A05

D

Anxiety and stress in children

Not recommended

A homeopathic preparation of antibodies to brain-specific protein S-100. It is promoted as a gentle calming remedy for anxiety and stress in children. Convincing benefit for this use has not been shown, and there is no evidence base for it here. What actually helps an anxious child is a steady sleep routine, support from family, and, when symptoms are marked, work with a child psychologist or therapist. Do not use this product in place of treatment with proven benefit, since that can mean missing the care a child needs.

Sources

  1. Journal of the American Academy of Child & Adolescent Psychiatry: Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents With Anxiety Disorders (2020)
  2. Bulletin of Experimental Biology and Medicine: Release-Activity: A Long Way from Phenomenon to New Drugs (2012)

ICD-10: F93 · ICD-11: 6B0Z

D

Generalized anxiety disorder

Not recommended

Release-active (homeopathic) antibodies to brain-specific protein S-100 are marketed as a calming remedy, including for anxiety. For generalized anxiety disorder the product has not shown convincing benefit, and there is no solid evidence base for this use. Generalized anxiety responds to approaches with proven effect: cognitive behavioral therapy and medications from the SSRI and SNRI groups, selected by a clinician. Do not take this product instead of a treatment with proven benefit, since that risks missing out on care that actually works.

Sources

  1. Sci Rep: The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders. (2021)
  2. Sci Rep: Retraction Note: The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders. (2022)
  3. Bull Exp Biol Med: Effects of tenoten on anxiety and depression disorders in patients with epilepsy. (2012)

ICD-10: F41.1 · ICD-11: 6B00

D

Insomnia and sleep disorders

Not recommended

Homeopathic antibodies to the brain-specific S-100 protein are marketed as a mild calming remedy, including for better sleep. The product has not shown convincing benefit for insomnia, and there is no solid evidence for this use. For ongoing sleep problems, other approaches help: sleep hygiene and cognitive behavioral therapy for insomnia, and when needed, medicines with proven effect chosen by a doctor. Do not use this remedy in place of treatment with proven benefit, or you risk missing out on effective care.

Sources

  1. AASM: Behavioral and psychological treatments for chronic insomnia disorder in adults (2021)
  2. Sleep Medicine Reviews: Homeopathy for insomnia: A systematic review of research evidence (2010)
  3. Sci Rep: The randomized clinical trial results of the anxiety treatment in patients with somatoform dysfunction and neurotic disorders. (2021)

ICD-10: G47.0 · ICD-11: 7A00

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

The manufacturer claims 'release-active' antibodies to the S-100 protein in homeopathic dilutions C12, C30, C50. The concentration of active substance corresponds to less than one molecule per therapeutic dose. By the laws of physics and chemistry, substances at these dilutions are absent. The described mechanism does not match modern molecular pharmacology. The Australia 2015 systematic review of homeopathy concluded that 'there is no reliable evidence of efficacy for any clinical condition'.

Safety

Contraindications

  • Hypersensitivity to any component
  • Age under 3 years (for adult formulation)
  • Lactase deficiency, lactose intolerance, glucose-galactose malabsorption

Serious adverse effects

  • Direct serious adverse events are unlikely due to absence of active substance
  • The clinically meaningful risk is delayed treatment of actual psychiatric disorders

Common adverse effects

  • Per manufacturer label: rare allergic reactions

Pregnancy: can you take Antibodies to S-100 brain-specific protein (homeopathic)?

Pregnancy safety data are limited. International sources do not recommend homeopathic products for any condition.

Breastfeeding: can you take Antibodies to S-100 brain-specific protein (homeopathic)?

Tenoten contains release-active (ultra-low) concentrations of antibodies to the S-100 brain protein, marketed as a homeopathic product. Systematic reviews and EMA do not confirm efficacy and the proposed mechanism of action lacks supporting evidence. There are no human milk transfer data. The drug is not registered in Spain and is not recommended during breastfeeding.

Calculate RID

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

Practical notes

Position on homeopathy

International scientific consensus: homeopathy is treatment with 'nothing'. Australia (2015), Swiss HTA (2006), and (2017) independently concluded that there is no clinical efficacy. The homeopathic principle of 'like cures like' at dilutions where the original substance is physically absent is incompatible with biochemistry and pharmacology.

Common myths

Myth: 'Tenoten is safe because it is homeopathy, at worst a placebo, no harm done'. Fact: homeopathic products are as safe as a sugar pill. But when a child or adult with an actual anxiety disorder receives Tenoten instead of seeing a therapist or getting an SSRI, that is missed care. The harm is indirect – delayed treatment and condition progression.

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Frequently asked

What is Antibodies to S-100 brain-specific protein (homeopathic) used for?

Antibodies to S-100 brain-specific protein (homeopathic) is evaluated for the following indications with varying evidence strength: Anxiety and stress in children (evidence tier D), Generalized anxiety disorder (evidence tier D), ADHD (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Antibodies to S-100 brain-specific protein (homeopathic)?

Common side effects of Antibodies to S-100 brain-specific protein (homeopathic) (≥ 1 in 100): Per manufacturer label: rare allergic reactions. See the Safety section for uncommon and serious reactions.

Is Antibodies to S-100 brain-specific protein (homeopathic) safe during pregnancy?

Pregnancy safety data are limited. International sources do not recommend homeopathic products for any condition.

Is Antibodies to S-100 brain-specific protein (homeopathic) compatible with breastfeeding?

Tenoten contains release-active (ultra-low) concentrations of antibodies to the S-100 brain protein, marketed as a homeopathic product. Systematic reviews and EMA do not confirm efficacy and the proposed mechanism of action lacks supporting evidence. There are no human milk transfer data. The drug is not registered in Spain and is not recommended during breastfeeding.

Who should not take Antibodies to S-100 brain-specific protein (homeopathic)?

Antibodies to S-100 brain-specific protein (homeopathic) is contraindicated in: Hypersensitivity to any component; Age under 3 years (for adult formulation); Lactase deficiency, lactose intolerance, glucose-galactose malabsorption. Full list in the Safety section.

Tenoten is safe because it is homeopathy, at worst a placebo, no harm done

homeopathic products are as safe as a sugar pill. But when a child or adult with an actual anxiety disorder receives Tenoten instead of seeing a therapist or getting an SSRI, that is missed care. The harm is indirect – delayed treatment and condition progression.

Official sources

Direct links to regulator labels. Open in a new tab.

Other drugs in this group

Deproteinized hemoderivative from calf blood, Anaferon (anti-human interferon gamma antibodies in homeopathic dilutions), Cerebrolysin (porcine brain peptides), Cobicistat, Ergoferon (antibodies to γ-interferon, CD4, and histamine in homeopathic dilutions), Ethylmethylhydroxypyridine succinate, Deferasirox, Methylthioninium chloride (methylene blue)