Evigrade

Chamomile (Matricaria chamomilla / recutita, flowers)

Herbal preparation, EMA HMPC traditional herbal medicinal product

ATC code: N05CX-CHAMOMILE

Brand names: Traditional Medicinals Chamomile, Nature's Way Chamomile, NOW Chamomile Flowers, Solgar Chamomile

Updated · Methodology

Indications

B

Functional dyspepsia

Adjunct

Chamomile is one of the best-evidenced herbal options for functional dyspepsia and mild GI spasm. HMPC in 2015 granted chamomile flowers well-established-use status for symptomatic treatment of mild gastrointestinal disturbances: flatulence, spasm and mild dyspepsia. Chamomile is part of Iberogast – a combined herbal product with RCT-proven efficacy in functional dyspepsia. Per Rome IV criteria, diagnosis rests on post-prandial fullness, early satiety and epigastric pain without organic pathology. Taking 1.5–3 g of dried flowers as tea three times a day or an equivalent extract for 2–4 weeks is a reasonable first step. If symptoms persist beyond a month, or weight loss, haematemesis or melaena appear, gastroscopy is needed, not herbal tea.

ICD-10: K30 · ICD-11: DD90.3

C

Stress and anxiety

Adjunct

Chamomile has moderate evidence for mild anxiety symptoms. Amsterdam et al. RCT (J Clin Psychopharmacol 2009) with chamomile extract 220 mg 1–5 times daily for 8 weeks in 57 patients with mild–moderate GAD showed a meaningful reduction in Hamilton anxiety scores vs placebo. Later studies by the same group gave mixed results, and no systematic review reaches a confident positive conclusion. HMPC recognises chamomile for mild nervous tension within traditional-use status. CG113 recommends CBT and SSRIs first-line for GAD – chamomile is only an add-on for mild symptoms. If chamomile was prescribed as monotherapy for diagnosed GAD or panic disorder in place of standard treatment, consider seeking a second opinion.

ICD-10: F41.9 · ICD-11: 6B0Z

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Immune support and “detox” (marketing category)

Not recommended

Chamomile flowers (Matricaria chamomilla) are a common herbal ingredient sold in teas and supplements for "immune support" and "detox". There is no convincing evidence that chamomile strengthens immunity or clears "toxins" from the body, and "detox" has no real medical meaning, since the liver and kidneys handle that on their own. To actually support your defenses, the things that work are well known: routine vaccination, enough sleep, varied nutrition and physical activity. In ordinary culinary amounts chamomile is safe, but you should not count on it for any immune effect.

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Chamomile flowers contain essential oils with bisabolol and chamazulene, the flavonoid apigenin and coumarins. Apigenin binds the benzodiazepine site of the GABA-A receptor – the proposed basis for a mild anxiolytic effect. Bisabolol and chamazulene relax intestinal smooth muscle and suppress prostaglandin synthesis in inflamed mucosa – the basis for use in functional dyspepsia. HMPC in 2015 granted chamomile traditional-use status for two indications: mild anxiety and mild functional dyspepsia. Apigenin bioavailability in humans is low, and plasma concentration after a standard extract dose barely reaches pharmacologically active levels.

Safety

Contraindications

  • Hypersensitivity to chamomile or other Asteraceae (ragweed, mugwort, yarrow) – risk of severe allergic reaction
  • Age under 6 for medicinal doses of concentrated products

Serious adverse effects

  • Rare anaphylaxis cases in severe Asteraceae allergy
  • Potentiation of warfarin from coumarins with long-term high-dose use

Common adverse effects

  • Allergic contact dermatitis with topical use
  • Nausea with large infusion volumes

Pregnancy: can you take Chamomile (Matricaria chamomilla / recutita, flowers)?

Chamomile as a weak tea (one cup of 1–2 g dried flowers) is considered safe in pregnancy and has been used for millennia. Concentrated extracts and essential oil at high doses are not studied in pregnancy RCTs and may theoretically stimulate uterine contractions. EMA HMPC does not recommend medicinal doses of concentrated products in pregnancy due to data gaps. AEMPS classifies the product as a traditional herbal medicinal product without a pregnancy indication.

Breastfeeding: can you take Chamomile (Matricaria chamomilla / recutita, flowers)?

Chamomile tea is compatible with breastfeeding per LactMed. Concentrated extracts and essential oil are not studied in nursing RCTs.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

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Frequently asked

What is Chamomile (Matricaria chamomilla / recutita, flowers) used for?

Chamomile (Matricaria chamomilla / recutita, flowers) is evaluated for the following indications with varying evidence strength: Functional dyspepsia (evidence tier B), Stress and anxiety (evidence tier C), Immune support and “detox” (marketing category) (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Chamomile (Matricaria chamomilla / recutita, flowers)?

Common side effects of Chamomile (Matricaria chamomilla / recutita, flowers) (≥ 1 in 100): Allergic contact dermatitis with topical use, Nausea with large infusion volumes. See the Safety section for uncommon and serious reactions.

Is Chamomile (Matricaria chamomilla / recutita, flowers) safe during pregnancy?

Chamomile as a weak tea (one cup of 1–2 g dried flowers) is considered safe in pregnancy and has been used for millennia. Concentrated extracts and essential oil at high doses are not studied in pregnancy RCTs and may theoretically stimulate uterine contractions. EMA HMPC does not recommend medicinal doses of concentrated products in pregnancy due to data gaps. AEMPS classifies the product as a traditional herbal medicinal product without a pregnancy indication.

Is Chamomile (Matricaria chamomilla / recutita, flowers) compatible with breastfeeding?

Chamomile tea is compatible with breastfeeding per LactMed. Concentrated extracts and essential oil are not studied in nursing RCTs.

Who should not take Chamomile (Matricaria chamomilla / recutita, flowers)?

Chamomile (Matricaria chamomilla / recutita, flowers) is contraindicated in: Hypersensitivity to chamomile or other Asteraceae (ragweed, mugwort, yarrow) – risk of severe allergic reaction; Age under 6 for medicinal doses of concentrated products. Full list in the Safety section.

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