Antiprotozoal and antibacterial, 5-nitroimidazole derivative
ATC code: P01AB02 (Tinidazole)
Brand names
Tindamax, Fasigyn
Activated by ferredoxin-dependent nitroreductase in anaerobic organisms and protozoa. Reduced metabolites damage DNA and cause cell death. Active against Trichomonas, Giardia, Entamoeba and anaerobic bacteria. Half-life is longer than metronidazole (12 hours), supporting single-dose regimens.
First line
Tinidazole is first-line for trichomoniasis in vaginitis and male partner, given as a single 2 g oral dose. SEIMC and CDC equate tinidazole with metronidazole, preferring tinidazole in metronidazole-resistant strains. Partner treatment is mandatory to prevent reinfection.
Opens the checker prefilled with this drug. Pick the second one from your regimen.
Contraindicated in the first trimester. In second and third trimesters use only when necessary.
Passes into milk. After single dose, interrupt breastfeeding for 72 hours.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
Tinidazole is evaluated for the following indications with varying evidence strength: Trichomoniasis (evidence tier A). See the full indication matrix with dosing and citations above on this page.
Common side effects of Tinidazole (≥ 1 in 100): Metallic taste, Nausea, Headache, Rash. See the Safety section for uncommon and serious reactions.
FDA category C. Contraindicated in the first trimester. In second and third trimesters use only when necessary.
Passes into milk. After single dose, interrupt breastfeeding for 72 hours.
Tinidazole is contraindicated in: First trimester of pregnancy; Alcohol use during and 72 hours after withdrawal (disulfiram-like reaction); Active blood disorders; Severe CNS disease. Full list in the Safety section.