Antiprotozoal and antibacterial, 5-nitroimidazole derivative
Brand names: Tindamax, Fasigyn
Updated · Methodology
First line
Tinidazole is first-line for trichomoniasis in vaginitis and male partner, given as a single 2 g oral dose. SEIMC and CDC equate tinidazole with metronidazole, preferring tinidazole in metronidazole-resistant strains. Partner treatment is mandatory to prevent reinfection.
Sources
ICD-10: A59 · ICD-11: 1A92
Activated by ferredoxin-dependent nitroreductase in anaerobic organisms and protozoa. Reduced metabolites damage DNA and cause cell death. Active against Trichomonas, Giardia, Entamoeba and anaerobic bacteria. Half-life is longer than metronidazole (12 hours), supporting single-dose regimens.
Contraindicated in the first trimester. In second and third trimesters use only when necessary.
Passes into milk. After single dose, interrupt breastfeeding for 72 hours.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
Verbatim lines from the interaction sections, in the language of the label
«Potential Effects of Tinidazole on Other Drugs: Alcohols, Disulfiram: Alcoholic beverages and preparations containing ethanol or propylene glycol should be avoided during tinidazole therapy and for 3…»FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: CYP3A4 inducers/FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Fluorouracil: Monitor for fluorouracil-associated toxicities ( 7.1 )»FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Cyclosporine, tacrolimus: Monitor for toxicities of these immunosuppressive drugs ( 7.1 )»FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Lithium: Monitor serum lithium concentrations ( 7.1 )»FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Phenytoin, fosphenytoin: Adjustment of anticonvulsant and/FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Cyclosporine, tacrolimus: Monitor for toxicities of these immunosuppressive drugs ( 7.1 )»FDA, section 7 · Open on DailyMed
«DRUG INTERACTIONS: Warfarin and other oral coumarin anticoagulants: Anticoagulant dosage may need adjustment during and up to 8 days after tinidazole therapy ( 7.1 )»FDA, section 7 · Open on DailyMed
«Potential Effects of Other Drugs on Tinidazole: CYP3A4 Inducers and Inhibitors: Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymes, i.e., CYP3A4 inducers such…»FDA, section 7 · Open on DailyMed
«Potential Effects of Other Drugs on Tinidazole: CYP3A4 Inducers and Inhibitors: Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymes, i.e., CYP3A4 inducers such…»FDA, section 7 · Open on DailyMed
«Laboratory Test Interactions: Tinidazole, like metronidazole, may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine…»FDA, section 7 · Open on DailyMed
«Potential Effects of Other Drugs on Tinidazole: CYP3A4 Inducers and Inhibitors: Simultaneous administration of tinidazole with drugs that induce liver microsomal enzymes, i.e., CYP3A4 inducers such…»FDA, section 7 · Open on DailyMed
«Potential Effects of Other Drugs on Tinidazole: Oxytetracycline: Oxytetracycline was reported to antagonize the therapeutic effect of metronidazole.»FDA, section 7 · Open on DailyMed
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Tinidazole is evaluated for the following indications with varying evidence strength: Trichomoniasis (evidence tier A). See the full indication matrix with dosing and citations above on this page.
Common side effects of Tinidazole (≥ 1 in 100): Metallic taste, Nausea, Headache, Rash. See the Safety section for uncommon and serious reactions.
Contraindicated in the first trimester. In second and third trimesters use only when necessary.
Passes into milk. After single dose, interrupt breastfeeding for 72 hours.
Tinidazole is contraindicated in: First trimester of pregnancy; Alcohol use during and 72 hours after withdrawal (disulfiram-like reaction); Active blood disorders; Severe CNS disease. Full list in the Safety section.
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