Recombinant protein vaccine
Updated · Methodology
First line
Hepatitis B during breastfeeding. Per CDC ACIP 2024 and SEGO 2023, fully compatible. If unvaccinated and in a risk group (healthcare worker, HBV+ partner, HIV+), vaccinate without interrupting breastfeeding.
Sources
ICD-10: Z23 · ICD-11: QC00
Contains hepatitis B surface antigen (HBsAg) produced recombinantly in yeast. Adjuvant – aluminum salts. Three-dose schedule (0-1-6 months) achieves protective titers (anti-HBs ≥10 mIU/mL) in 95% of adults, 50–70% in immunocompromised. Lifelong immunity after full series.
Use in pregnancy when indicated. Safe.
Fully compatible. Hale L1.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
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Hepatitis B vaccine, recombinant is evaluated for the following indications with varying evidence strength: Vaccination during breastfeeding (evidence tier A). See the full indication matrix with dosing and citations above on this page.
Common side effects of Hepatitis B vaccine, recombinant (≥ 1 in 100): Injection-site pain (10–30%), Fatigue, Headache. See the Safety section for uncommon and serious reactions.
Use in pregnancy when indicated. Safe.
Fully compatible. Hale L1.
Hepatitis B vaccine, recombinant is contraindicated in: Anaphylaxis to previous dose or components (yeast); Acute febrile illness (defer). Full list in the Safety section.
HPV vaccine, nonavalent, Inactivated influenza vaccine, MMR – measles, mumps, rubella vaccine (live), Pneumococcal conjugate vaccine PCV20, Tdap – tetanus, diphtheria, acellular pertussis vaccine, COVID-19 vaccine, mRNA (Pfizer-BioNTech), RSV vaccine, recombinant (maternal), COVID-19 vaccine, mRNA (Moderna)