Lactational mastitis
First line
MSSA lactational mastitis. Per CKS 2023 and UK Drug Tariff, first-line in UK and Spain at 500 mg 4 times daily for 10-14 days. Alternative – cephalexin (equivalent efficacy). Penicillin-intolerant – clindamycin.
Beta-lactamase-resistant penicillin
ATC code: J01CF05 (Flucloxacillin)
Narrow-spectrum isoxazolyl penicillin resistant to staphylococcal beta-lactamase. Bactericidal against MSSA, Streptococcus pyogenes, Streptococcus pneumoniae. Not active against MRSA. Bioavailability 50-70%, better on empty stomach.
First line
MSSA lactational mastitis. Per CKS 2023 and UK Drug Tariff, first-line in UK and Spain at 500 mg 4 times daily for 10-14 days. Alternative – cephalexin (equivalent efficacy). Penicillin-intolerant – clindamycin.
Opens the checker prefilled with this drug. Pick the second one from your regimen.
Safe in pregnancy.
Compatible. Hale L1. RID about 0.3%, minimal infant exposure.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
Flucloxacillin is evaluated for the following indications with varying evidence strength: Lactational mastitis (evidence tier A). See the full indication matrix with dosing and citations above on this page.
Common side effects of Flucloxacillin (≥ 1 in 100): Nausea, Diarrhea, Skin rash. See the Safety section for uncommon and serious reactions.
FDA category B. Safe in pregnancy.
Compatible. Hale L1. RID about 0.3%, minimal infant exposure.
Flucloxacillin is contraindicated in: Anaphylaxis to penicillins; History of flucloxacillin-induced hepatotoxicity. Full list in the Safety section.