Combined metabolic preparations (local classification). Russian development.
ATC code: A11JA-BIOTREDIN (Biotredin (L-threonine + pyridoxine) – local code)
Biotredin is a fixed combination of L-threonine and pyridoxine (vitamin B6). The manufacturer claims that in brain neurons L-threonine converts to glycine and the combination raises intracerebral glycine and normalises GABAergic transmission. Developed in Russia and registered for alcohol dependence and reduced mental performance in children and adults. Absent from international guidelines. Independent international RCTs are unavailable.
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
Not recommended
L-threonine with pyridoxine (sold as Biotredin) is a metabolic supplement marketed to ease the morning after drinking and curb alcohol craving. No solid evidence shows the combination helps with a hangover or alcohol recovery, and the studies behind this use are low quality. What actually helps after drinking is time, fluids, and rest; heavy vomiting or marked dehydration is a reason to see a doctor.
Not recommended
Biotredin combines L-threonine and pyridoxine (vitamin B6) and is marketed to improve memory and concentration. There is no convincing evidence of benefit for this use: studies confirming an effect on memory and attention are lacking. What actually helps memory and focus is good sleep, regular physical activity, treating anxiety or depression when present, and managing vascular risk factors; if memory problems persist, see a doctor for assessment.
Not recommended
Biotredin is a combination of L-threonine and pyridoxine (vitamin B6) sold in Russia as an amino-acid complex for nervous-system support and youth extension. The evidence base is limited to in-house studies by the manufacturer; no independent international clinical studies exist. Biotredin is not included in any international guidelines. The idea of youth extension through amino-acid supplements is not supported by clinical evidence. The supplement is relatively safe, but no anti-aging effect should be expected. If biotredin was recommended for rejuvenation, consider seeking a second opinion.
Opens the checker prefilled with this drug. Pick the second one from your regimen.
Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
L-threonine + pyridoxine (Biotredin) is evaluated for the following indications with varying evidence strength: Memory and concentration enhancement (evidence tier D), Hangover recovery (evidence tier D), Anti-aging and longevity (evidence tier F). See the full indication matrix with dosing and citations above on this page.
Common side effects of L-threonine + pyridoxine (Biotredin) (≥ 1 in 100): Transient dizziness, Increased sweating, Allergic reactions (rare). See the Safety section for uncommon and serious reactions.
FDA category N. Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
L-threonine + pyridoxine (Biotredin) is contraindicated in: Concurrent MAO inhibitor antidepressants; Hypersensitivity. Full list in the Safety section.