Dietary supplements, redox cofactors (local classification)
ATC code: A11JA-PQQ (Pyrroloquinoline quinone (PQQ) – local code)
Brand names
Doctor's Best PQQ, BioPQQ, Life Extension PQQ Caps
Pyrroloquinoline quinone is a redox cofactor found in bacteria, fermented natto soy, parsley, and green peppers. Manufacturers claim mitochondrial biogenesis stimulation via PGC-1α, CREB, and NRF2 activation based on cellular and rodent data. In humans, published RCTs with mitochondrial density endpoints do not exist.
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
Not recommended
Pyrroloquinoline quinone (PQQ) is sold as a supplement to slow aging and extend lifespan, with promises of mitochondrial support and more cellular energy. No convincing benefit for this use has been shown in people, and there is no evidence base for anti-aging or longevity. What actually affects aging and lifespan is sleep, diet, physical activity and not smoking.
Not recommended
Pyrroloquinoline quinone (PQQ) is a compound with antioxidant properties, sold as a supplement "for energy" and marketed as a way to relieve chronic fatigue. PQQ has not shown convincing benefit for this condition, and there is no good-quality evidence that it works here. With persistent fatigue, the first step is to find and treat the underlying cause (sleep, iron deficiency, thyroid problems, depression, chronic illness) together with a doctor. PQQ is safe in this use, but it does not replace treatments with proven benefit, and relying on it instead of proper workup and care delays real help.
Not recommended
Pyrroloquinoline quinone (PQQ) is sold as a supplement for memory and concentration. In people, no convincing benefit for this use has been shown – the evidence for it is missing. What actually helps memory and attention is sleep, physical activity, treating underlying causes (such as iron deficiency or thyroid problems) and managing vascular risk factors. Do not take PQQ instead of an approach with proven benefit, or you may miss the treatment you need.
Opens the checker prefilled with this drug. Pick the second one from your regimen.
Use in pregnancy has not been studied; supplement is not recommended.
Use during breastfeeding has not been studied; supplement is not recommended.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
Pyrroloquinoline quinone (PQQ) is evaluated for the following indications with varying evidence strength: Anti-aging and longevity (evidence tier D), Memory and concentration enhancement (evidence tier D), Chronic fatigue (evidence tier D). See the full indication matrix with dosing and citations above on this page.
Common side effects of Pyrroloquinoline quinone (PQQ) (≥ 1 in 100): Headache, GI discomfort, Irritability, sleep disturbance (at high doses). See the Safety section for uncommon and serious reactions.
FDA category N. Use in pregnancy has not been studied; supplement is not recommended.
Use during breastfeeding has not been studied; supplement is not recommended.
Pyrroloquinoline quinone (PQQ) is contraindicated in: Pregnancy and breastfeeding; Age under 18; Hypersensitivity. Full list in the Safety section.