Pterostilbene (dimethyl resveratrol analogue)

Pterostilbene is a natural polyphenol, a dimethylated analogue of resveratrol. It is marketed as a supplement to improve memory and concentration. So far it has not shown convincing benefit for this use: there is no solid evidence for an effect on cognition in people. What actually helps memory and focus is sleep, regular physical activity, and managing vascular risk factors; for persistent complaints it makes sense to discuss the cause with a doctor.

Pterostilbene is sold as a «natural cardioprotector». Riche 2014 RCT in 80 patients with dyslipidaemia paradoxically showed LDL increase by 10–15% with pterostilbene 250 mg/day × 6–8 weeks vs placebo. No systematic reviews with positive lipid effect. ESC dyslipidaemia 2024 at LDL >1.8–3.0 mmol/L (depending on CV risk) lists statins (atorvastatin, rosuvastatin) first-line; if not at goal – ezetimibe, PCSK9 inhibitors or bempedoic acid; pterostilbene is not in guidelines and may potentially worsen the lipid profile. If pterostilbene was recommended for hypercholesterolaemia, consider seeking a second opinion from a cardiologist.

Pterostilbene is actively sold in the longevity segment as «improved resveratrol» with better bioavailability, often combined with nicotinamide riboside (NR) in Basis by Elysium Health. No RCTs with lifespan, biological ageing slowing (Horvath/GrimAge epigenetic clocks) or all-cause mortality endpoints in humans. Memorial Sloan Kettering 2024 resveratrol and analogues monograph notes «no clinical evidence for anti-aging or longevity claims». Most claims rest on mouse model translation (David Sinclair et al.) and in vitro SIRT1 activation. Proven lifespan measures: smoking cessation, blood pressure, glucose, body weight control, physical activity, Mediterranean diet. If pterostilbene was recommended as part of an anti-aging protocol, consider seeking a second opinion from a general practitioner.