Spermidine

Spermidine is a polyamine found in foods such as wheat germ, soy, mushrooms and aged cheese, and as a supplement it gets promoted for slowing aging and extending lifespan. The interest comes from cell and animal studies where spermidine triggered autophagy, but convincing benefit for this use has not been shown in people: there are no high-quality long-term trials with hard outcomes. Healthy aging rests on well-established habits – a balanced diet, regular physical activity, enough sleep, not smoking and keeping cardiovascular risk factors in check.

Spermidine is a natural polyamine sold as a supplement for memory and focus, citing its role in autophagy and animal studies. In people, no convincing benefit for memory or attention has been shown, and the evidence for this use is lacking. Cognition is better supported by sleep, physical activity, and controlling blood pressure and glucose, with a medical check-up if memory problems persist.