Evigrade

Maca

Botanical supplement, Peruvian maca root (Lepidium meyenii), marketed for male and female sexual function

ATC code: A11JA-MACA

Brand names – supplements: Maca Gold, NOW Maca, Gaia Herbs Maca, Navitas Organics MacaSupplements are not tested in clinical trials and are not registered as medications.

Updated · Methodology

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

D

Erectile dysfunction

Not recommended

Maca is an over-the-counter supplement. The Shin systematic review (BMC Complement Altern Med 2010) pooled 4 RCTs with 131 participants: at 1.5–3 g/day for 12 weeks in men with mild erectile dysfunction, maca gave a small improvement on the IIEF questionnaire versus placebo. Effect size was small, methodology weak and investigator funding by Peruvian maca producers not fully disclosed. Current AUA 2018 and EAU 2024 ED guidelines recommend PDE-5 inhibitors (sildenafil, tadalafil) as first line, testosterone screening, cardiovascular risk assessment and lifestyle factors. Maca is not in international guidelines. If maca was bought instead of seeing a urologist for persistent erectile problems, discuss with a doctor; ED can be the first sign of occult coronary disease and type 2 diabetes.

ICD-10: N52.9 · ICD-11: HA01.1

D

Superfoods and adaptogens (marketing category)

Not recommended

Maca is the root of a Peruvian plant (Lepidium meyenii), sold as a superfood and adaptogen. In this category it gets promoted for energy, libido, stamina and easing menopausal symptoms. Studies have not shown convincing benefit for these claimed effects: there is no solid evidence base for this use. If low energy, libido problems or menopausal symptoms bother you, a doctor can help pin down the cause and choose an approach with proven benefit. Maca should not be taken in place of treatment with established benefit, so you do not miss out on the care you need.

How to read tiers A–F
  • AStrong evidence – first or second line in international guidelines
  • BRecommended in selected cases
  • CStudy data contradict each other
  • DBenefit not proven, no documented harm
  • FDocumented harm, or risk without benefit

Mechanism of action

Maca is a Brassicaceae root crop native to the Peruvian Andes (3500–4500 metres). It contains macamides and macaenes (unique fatty amides), glucosinolates, sterols and amino acids. The mechanism in humans is unknown. Unlike classic aphrodisiacs, maca does not bind sex-hormone receptors and does not change testosterone, oestradiol, LH or FSH levels in RCTs (Stone 2009, Gonzales 2003). in 2011 rejected all health claims for maca on energy, stamina and sexual function due to insufficient cause-and-effect substantiation. AESAN classifies maca as a complemento alimenticio without therapeutic indication.

Safety

Contraindications

  • Known hypersensitivity to Lepidium meyenii or Brassicaceae
  • Hormone-dependent tumours (breast, endometrial, prostate cancer) – theoretical risk from weak phytoestrogen activity
  • Severe thyroid dysfunction without endocrinology follow-up

Serious adverse effects

  • Isolated reports of blood-pressure elevation in predisposed users

Common adverse effects

  • Gastrointestinal discomfort, flatulence
  • Insomnia and restlessness when taken later in the day
  • Headache at higher doses

Pregnancy: can you take Maca?

Maca safety in human pregnancy has not been studied in RCTs. High-dose Brassicaceae glucosinolates theoretically bind iodine and load the thyroid. EFSA has set no safe maca dose for pregnant women. AESAN classifies maca as a complemento alimenticio without therapeutic indication; supplementation in pregnancy is not justified.

Breastfeeding: can you take Maca?

Maca safety in lactation has not been studied in RCTs. No data on transfer of macamides and glucosinolates into human milk. Supplementation with maca during lactation is not justified.

Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.

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Frequently asked

What is Maca used for?

Maca is evaluated for the following indications with varying evidence strength: Erectile dysfunction (evidence tier D), Superfoods and adaptogens (marketing category) (evidence tier D). See the full indication matrix with dosing and citations above on this page.

What are the side effects of Maca?

Common side effects of Maca (≥ 1 in 100): Gastrointestinal discomfort, flatulence, Insomnia and restlessness when taken later in the day, Headache at higher doses. See the Safety section for uncommon and serious reactions.

Is Maca safe during pregnancy?

Maca safety in human pregnancy has not been studied in RCTs. High-dose Brassicaceae glucosinolates theoretically bind iodine and load the thyroid. EFSA has set no safe maca dose for pregnant women. AESAN classifies maca as a complemento alimenticio without therapeutic indication; supplementation in pregnancy is not justified.

Is Maca compatible with breastfeeding?

Maca safety in lactation has not been studied in RCTs. No data on transfer of macamides and glucosinolates into human milk. Supplementation with maca during lactation is not justified.

Who should not take Maca?

Maca is contraindicated in: Known hypersensitivity to Lepidium meyenii or Brassicaceae; Hormone-dependent tumours (breast, endometrial, prostate cancer) – theoretical risk from weak phytoestrogen activity; Severe thyroid dysfunction without endocrinology follow-up. Full list in the Safety section.

Other drugs in this group

Mixed tocopherols, Monolaurin (glycerol monolaurate), Mucuna pruriens (velvet bean), Myo-inositol, Propolis (bee product), Spermidine, Artichoke (Cynara scolymus), Cranberry (Vaccinium macrocarpon)