Cardiovascular prevention through supplements
Not recommended
Krill oil is an OTC supplement with claimed EPA/DHA load in fewer capsules than standard fish oil. in 2010 approved an EPA+DHA claim at 250 mg/day for normal heart function – the wording is source-agnostic (fish oil, krill oil, algal omega-3). No RCT has shown a krill-oil effect on hard cardiovascular outcomes (MI, stroke, CV death). Statins and non-pharmacological measures – blood-pressure and glucose control, smoking cessation, 150 min/week activity, Mediterranean diet – have orders-of-magnitude stronger evidence ( 2021, SEC 2022). If krill oil was bought to replace a prescribed statin, discuss with a cardiologist; stopping a statin in confirmed coronary disease multiplies infarction risk. EPA/DHA supplementation may be considered as an add-on in severe hypertriglyceridaemia above 5 mmol/L in agreement with the treating doctor.
Sources
- EFSA NDA Panel: Scientific Opinion on EPA and DHA contribution to the normal function of the heart (250 mg/day claim) (2010)
- Lipids (Ulven et al.): Metabolic effects of krill oil are essentially similar to those of fish oil, but at lower dose of EPA and DHA (2011)
- ESC: ESC Guidelines on cardiovascular disease prevention in clinical practice (2021)
- SEC: Sociedad Espanola de Cardiologia, comentario a las guias ESC 2021 de prevencion cardiovascular (2022)