Nootropics (local classification). Russian development.
Updated · Methodology
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
Not recommended
For non-clinical chronic fatigue, noopept is used as a «tonic nootropic». Independent RCTs with validated fatigue scale endpoints (FSS, MFI-20) in healthy adults do not exist. Absent from international guidelines.
Sources
ICD-10: R53 · ICD-11: MG22
Not recommended
Noopept is a Russian synthetic nootropic promoted in biohacker and student communities as a new-generation drug for concentration before exams or deadlines. Outside Russia it is sold through grey-market channels as a dietary supplement. There are no independent international clinical studies in healthy adults: effects on working memory, attention, or productivity have not been confirmed. The , , and AEMPS have not approved noopept. It is not included in any international clinical guidelines. If noopept was recommended for concentration, exam preparation, or after a head injury, consider seeking a second opinion: there is no evidence base for these uses.
Noopept is a synthetic dipeptide analogue of piracetam with a claimed potency 1000 times higher at comparable doses. Developed at the Zakusov Research Institute of Pharmacology. The manufacturer claims cholinergic, antioxidant, and neuroprotective action and increased hippocampal BDNF and NGF in rodents. In humans, large independent RCTs with validated cognitive scale endpoints do not exist.
Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
Reference information, not a clinical decision. Discuss feeding pauses or changes with your physician or an IBCLC.
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Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is evaluated for the following indications with varying evidence strength: Chronic fatigue (evidence tier F), Memory and concentration enhancement (evidence tier F). See the full indication matrix with dosing and citations above on this page.
Common side effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) (≥ 1 in 100): Allergic reactions, Blood pressure rise in patients with hypertension, Irritability, sleep disturbance. See the Safety section for uncommon and serious reactions.
Contraindicated in pregnancy per label.
Contraindicated during breastfeeding per label.
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is contraindicated in: Pregnancy and breastfeeding; Age under 18 (per Russian label); Severe hepatic or renal disease; Hypersensitivity. Full list in the Safety section.
Paroxetine, Phenelzine, Phenylpiracetam (fonturacetam), Phosphatidylserine, Rivastigmine, 5-hydroxytryptophan (5-HTP), Citicoline, Glycine (as a marketed «nootropic»)