Fabomotizole

Fabomotizole (brand name Afobazole) is an anxiolytic marketed in Russia as a "mild" anti-anxiety option, including for generalized anxiety disorder. Studies have not shown convincing benefit for this use: international guidelines and evidence reviews do not cover it, and there are no quality RCTs that confirm an effect. For generalized anxiety disorder, the approaches with proven benefit are cognitive behavioral therapy and antidepressants from the SSRI or SNRI groups. Fabomotizole should not replace them, because swapping proven treatment for this drug risks losing time without real help

ICD-10: F41.1 · ICD-11: 6B00

Fabomotizole is an anxiolytic promoted to ease anxiety and also marketed for sleep problems. For insomnia specifically it has not shown convincing benefit, and there is no solid evidence base for this use. For chronic insomnia, international guidelines put cognitive behavioral therapy for insomnia (CBT-I) first, with a clinician choosing a sleep medication for short-term use when needed. The substance itself is harmless in this role, but do not take it instead of a treatment with proven benefit, since that risks missing real care. Decide together with your doctor

ICD-10: G47.0 · ICD-11: 7A00

Fabomotizole is an anxiolytic sold and promoted in Russia for relief of stress and anxiety. Convincing benefit for this use has not been shown: international guidelines and reviews do not mention the drug, and the available data are too weak to support an effect. In this use the substance is well tolerated and carries no known harm, but there is little reason to expect help from it. For persistent anxiety, psychotherapy (cognitive behavioral therapy in particular) and medicines with an established evidence base, chosen by a doctor, are what work.

ICD-10: F41.9 · ICD-11: 6B0Z

For PMS, ACOG 2023 and RCOG international guidelines recommend CBT, selective serotonin reuptake inhibitors (sertraline, fluoxetine, citalopram) for marked symptoms, and combined oral contraceptives. Afobazole is not included.

ICD-10: N94.3 · ICD-11: GA34.40