Azelaic Acid

Naturally derived dicarboxylic acid with antibacterial, sebum-regulating, and depigmenting properties. One of the few prescription-grade ingredients considered safe in pregnancy.

AcneBrighteningSoothing

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

Approved by FDA and EMA for rosacea and acne. Systematic reviews confirm efficacy for post-acne hyperpigmentation and melasma. Depigmentation mechanism involves selective cytotoxicity toward abnormally active melanocytes.

Dreno B et al. J Eur Acad Dermatol Venereol. 2017;31(7):1121-1128.
Searle T et al. J Dermatol Treat. 2022;33(2):722-731.

Working concentrations

10–20% (Finacea 15%, Skinoren 20%)

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Caution

Skin types

Suitable for

OilyCombinationSensitiveNormal

Combinations with other ingredients

Works well with

TretinoinТретиноин

Used by dermatologists for melasma and acne. Tretinoin accelerates turnover, azelaic acid reduces pigmentation and inflammation.

NiacinamideНиацинамид

Both molecules work against post-acne pigmentation and inflammation. Gentle tolerability even on reactive skin.

Frequently asked questions

Is Azelaic Acid safe during pregnancy?

Azelaic Acid should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.

What skin types is Azelaic Acid for?

Azelaic Acid suits: oily, combination, sensitive, normal.