Evigrade

Soothing ingredients for sensitive skin

Ingredients that reduce reactivity, redness, and discomfort. From centella to madecassoside.

369 ingredients in database · 251 with tier A/B evidence · 273 safe in pregnancy

All ingredients in this category

369 ingredients

Highest-evidence picks

What to know

Soothing ingredients reduce inflammatory cascades in the skin. Centella asiatica (Cica) and its standardised extract TECA contain madecassoside and asiaticoside – triterpenic saponins that stimulate type I collagen synthesis and suppress inflammatory cytokines. It is the flagship of Korean sensitive-skin lines.

Bisabolol (from chamomile or synthetic) is a monoterpene with proven anti-inflammatory action. It also boosts the penetration of other actives across the skin barrier. Allantoin and panthenol (provitamin B5) accelerate regeneration and reduce irritation; both are safe in pregnancy and baby skincare.

Licochalcone A from liquorice (Glycyrrhiza inflata) is the key active in Eucerin Anti-Redness and Eucerin Dermo-Pure, blocking NF-κB and suppressing the pro-inflammatory cytokines IL-6 and TNF-α. Dipotassium glycyrrhizate is a gentler cousin acting on the same pathways and common in value-priced reactive-skin formulas.

For rosacea-reactive skin, a doctor may add topical vasoconstrictors (brimonidine, oxymetazoline) or ivermectin when Demodex is involved. A plain moisturiser without retinoids, acids, or fragrance is the foundation of any «soothing» routine.

What to avoid with sensitive skin: citrus (lemon, bergamot, grapefruit) and lavender essential oils – their oxidised terpene forms are potent contact allergens. Fragrance (the Parfum ingredient) is the leading cause of cosmetic contact dermatitis. Ethanol above 10%.

Frequently asked

How many soothing ingredients are in the Evigrade database?

Evigrade currently tracks 369 ingredients in the «soothing» category. Of those, 251 carry evidence tier A or B.

Which soothing ingredients are safe during pregnancy?

273 ingredients in this category are flagged as safe during pregnancy at typical cosmetic concentrations. Always confirm the choice with an OB-GYN.

Which ingredients suit sensitive skin?

347 ingredients in this category show both low irritation potential and low allergen risk, making them safe even for reactive and sensitised skin. A patch test is still advisable before first use.

How should I start using ingredients from this category?

Start with a single high-evidence ingredient (tier A or B) at a low concentration, 2–3 times per week. After 2–3 weeks without reaction, frequency can be increased. Do not introduce two new actives at once – if skin reacts, you won't know which one caused it.