Hydroxypalmitoyl Sphinganine
A ceramide-related lipid. It helps rebuild the barrier and hold moisture and supports calm skin. Well tolerated.
Evidence by route
Topical application
A barrier-restoring lipid. Safe, well tolerated.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Hydroxypalmitoyl Sphinganine is a lipid related to ceramides, derived from sphinganine. In cosmetics it is used as a barrier-repair ingredient: it supplies a lipid building block akin to those skin uses naturally, helps retain water and supports a calm, comfortable feel. It appears in creams and serums for damaged barrier and reactive skin. On efficacy there is a coherent basis. Ceramide-type lipids and their precursors make sense for reinforcing the barrier and reducing water loss, and this component fits that role. It works well as a barrier-supporting active within a well-built formula, especially combined with other physiological lipids. For topical use in pregnancy and breastfeeding there are no risk signals. Systemic absorption from skin is minimal, so it can be used in these stages. Tolerance is good. Low irritation and low allergy potential, especially suited to sensitive skin and a compromised barrier. Most people see no reactions.
Frequently asked questions
Is Hydroxypalmitoyl Sphinganine safe during pregnancy?
Hydroxypalmitoyl Sphinganine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hydroxypalmitoyl Sphinganine for?
Hydroxypalmitoyl Sphinganine suits: normal, dry, combination, oily, sensitive.
What is Hydroxypalmitoyl Sphinganine and what does it do in cosmetics?
A ceramide-related lipid.
What's the INCI name for Hydroxypalmitoyl Sphinganine?
The INCI name is Hydroxypalmitoyl Sphinganine. It may also appear as: Phytosphingosine derivative.
See Hydroxypalmitoyl Sphinganine in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Similar role in the formula
Explore by category
Published: · updated: