Cationized hyaluronate with better deposition on negatively charged skin/hair surfaces. Functional formulation ingredient with no standalone activity on the skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Inert formulation ingredient. Safe, no standalone activity.
Hydroxypropyltrimonium Hyaluronate is a cationized (positively charged) form of hyaluronic acid. The positive charge lets it deposit better on the negatively charged surface of hair and skin – it lasts longer after rinsing. Where applied. Shampoos, conditioners, hair masks, moisturizing serums (0.1-1%). Especially valued in formulas for damaged hair and dry scalp. In Spain in Sesderma Hyaluronic, Kerastase, L'Oréal Professionnel Pro Longer. Evidence base. Industry studies (Ashland, Lubrizol) show better moisture retention in hair and reduced combing friction. Direct clinical RCTs on skin are few; data extrapolated from regular hyaluronic acid. Safety. CIR rated hydroxypropyltrimonium hyaluronic acid derivatives safe at cosmetic concentrations (2014). Irritation and sensitization are rare. Pregnancy and lactation – safe topically. Suitable for all skin and hair types.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Hydroxypropyltrimonium Hyaluronate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Cationized hyaluronate with better deposition on negatively charged skin/hair surfaces.
The INCI name is Hydroxypropyltrimonium Hyaluronate. It may also appear as: Гидроксипропилтримоний гиалуронат.
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