Hydroxypropyltrimonium Hyaluronate
Cationized hyaluronate with better deposition on negatively charged skin/hair surfaces. Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Inert formulation ingredient. Safe, no standalone activity.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Hydroxypropyltrimonium Hyaluronate is a cationized (positively charged) form of hyaluronic acid. The positive charge lets it deposit better on the negatively charged surface of hair and skin – it lasts longer after rinsing. Where applied. Shampoos, conditioners, hair masks, moisturizing serums (0.1-1%). Especially valued in formulas for damaged hair and dry scalp. In Spain in Sesderma Hyaluronic, Kerastase, L'Oréal Professionnel Pro Longer. Evidence base. Industry studies (Ashland, Lubrizol) show better moisture retention in hair and reduced combing friction. Direct clinical RCTs on skin are few; data extrapolated from regular hyaluronic acid. Safety. CIR rated hydroxypropyltrimonium hyaluronic acid derivatives safe at cosmetic concentrations (2014). Irritation and sensitization are rare. Pregnancy and lactation – safe topically. Suitable for all skin and hair types.
Frequently asked questions
Is Hydroxypropyltrimonium Hyaluronate safe during pregnancy?
Hydroxypropyltrimonium Hyaluronate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Hydroxypropyltrimonium Hyaluronate and what does it do in cosmetics?
Cationized hyaluronate with better deposition on negatively charged skin/hair surfaces.
What's the INCI name for Hydroxypropyltrimonium Hyaluronate?
The INCI name is Hydroxypropyltrimonium Hyaluronate.
See Hydroxypropyltrimonium Hyaluronate in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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