Madecassic Acid
Centella triterpene acid. With asiaticoside it forms TECA – a clinically proven wound-healing preparation.
Evidence by route
Topical application
TECA active component – anti-inflammatory, accelerates regeneration. Clinical evidence in scars and atopic dermatitis.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Madecassic Acid is a pentacyclic triterpenoid, one of the four key active components of Centella asiatica (alongside madecassoside, asiatic acid, asiaticoside). Pure form is used in premium post-procedure and recovery products. Mechanism. Stimulates type I and III collagen synthesis in fibroblasts via TGF-β/Smad signaling (Bonté 1994, Maquart 1990). Suppresses TNF-α and IL-1β. Enhances dermal microcirculation, accelerates wound healing. Where applied. Post-procedure serums and creams for recovery after laser, chemical peels, microneedling. At 0.1–0.5%. Often combined with asiaticoside and madecassoside (TECA, Titrated Extract of Centella Asiatica). In Spain in Endocare Repair, Sesderma Cicasilk, Mesoestetic Post-procedure. Evidence base. Clinical studies of the TECA complex (containing madecassic acid) showed 25–30% faster epithelialization of postoperative wounds (Brinkhaus 2000, n=100). The Bylka 2013 systematic review confirmed efficacy for wounds, burns, and pressure ulcers. Standalone RCTs of pure madecassic acid are virtually absent. Safety. CIR confirmed safety at concentrations up to 0.5%. Non-comedogenic. Allergic reactions are rare (1–3% of eczema patients). Does not photosensitize. Pregnancy and lactation – topically with caution. Topical use at cosmetic concentrations is acceptable, but direct pregnancy data are limited. Oral centella in supplement doses is contraindicated in pregnancy (possible estrogen-like activity). Alternatives – adenosine, panthenol, niacinamide.
Frequently asked questions
Is Madecassic Acid safe during pregnancy?
Madecassic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Madecassic Acid for?
Madecassic Acid suits: normal, dry, oily, combination, sensitive.
What is Madecassic Acid and what does it do in cosmetics?
Centella triterpene acid.
What's the INCI name for Madecassic Acid?
The INCI name is Madecassic Acid.
See Madecassic Acid in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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Barrier repair, Soothing, Compromised barrier rebuild, Post-procedure recovery
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