Centella triterpene acid. With asiaticoside it forms TECA – a clinically proven wound-healing preparation.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
TECA active component – anti-inflammatory, accelerates regeneration. Clinical evidence in scars and atopic dermatitis.
Madecassic Acid is a pentacyclic triterpenoid, one of the four key active components of Centella asiatica (alongside madecassoside, asiatic acid, asiaticoside). Pure form is used in premium post-procedure and recovery products. Mechanism. Stimulates type I and III collagen synthesis in fibroblasts via TGF-β/Smad signaling (Bonté 1994, Maquart 1990). Suppresses TNF-α and IL-1β. Enhances dermal microcirculation, accelerates wound healing. Where applied. Post-procedure serums and creams for recovery after laser, chemical peels, microneedling. At 0.1–0.5%. Often combined with asiaticoside and madecassoside (TECA, Titrated Extract of Centella Asiatica). In Spain in Endocare Repair, Sesderma Cicasilk, Mesoestetic Post-procedure. Evidence base. Clinical studies of the TECA complex (containing madecassic acid) showed 25–30% faster epithelialization of postoperative wounds (Brinkhaus 2000, n=100). The Bylka 2013 systematic review confirmed efficacy for wounds, burns, and pressure ulcers. Standalone RCTs of pure madecassic acid are virtually absent. Safety. CIR confirmed safety at concentrations up to 0.5%. Non-comedogenic. Allergic reactions are rare (1–3% of eczema patients). Does not photosensitize. Pregnancy and lactation – topically with caution. Topical use at cosmetic concentrations is acceptable, but direct pregnancy data are limited. Oral centella in supplement doses is contraindicated in pregnancy (possible estrogen-like activity). Alternatives – adenosine, panthenol, niacinamide.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Madecassic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Madecassic Acid suits: normal, dry, oily, combination, sensitive.
Centella triterpene acid.
The INCI name is Madecassic Acid. It may also appear as: мадекассовая кислота.
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