Linolenic Acid
Essential omega-3 fatty acid. Restores skin barrier in EFA deficiency states, anti-inflammatory potential.
Evidence by route
Topical application
Essential fatty acid with RCT-confirmed barrier effect.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Linolenic Acid (ALA, alpha-linolenic acid) is an essential omega-3 fatty acid with three double bonds. In skin it acts as a structural component of cell membranes and a precursor of anti-inflammatory lipid mediators (resolvins, protectins). Mechanism. Integrates into keratinocyte phospholipids and stratum corneum intercellular lipids, reducing transepidermal water loss (TEWL). Through metabolism to eicosapentaenoic acid and resolvins it suppresses IL-1β and TNF-α in skin (Calder 2017). Where applied. Barrier-repair serums, atopic dermatitis creams, sensitive skin products. Natural sources: rosehip oil (32%), flaxseed oil (50–55%), chia oil (60%), kiwi seed oil (60%). In Spain in Sesderma, Martiderm Atopic, Avène Trixera lines. Evidence base. An RCT in atopic dermatitis (Bamford 2013) showed a 22% SCORAD reduction over 8 weeks with topical high-linolenic oil. No systematic review of topical use exists yet – the main evidence base covers oral intake. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Oxidizes in air – formulas require antioxidants (tocopherol) and opaque packaging. Pregnancy and lactation – safe. A good option for gestational xerosis and pregnancy-related atopy instead of retinoids. Suitable for nipple cracks during breastfeeding (rosehip oil is in Bepanthen Sensiderm).
Frequently asked questions
Is Linolenic Acid safe during pregnancy?
Linolenic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Linolenic Acid for?
Linolenic Acid suits: normal, dry, oily, combination, sensitive.
What is Linolenic Acid and what does it do in cosmetics?
Essential omega-3 fatty acid.
What's the INCI name for Linolenic Acid?
The INCI name is Linolenic Acid. It may also appear as: α-Linolenic Acid.
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Lysolecithin, Madecassic Acid, Olea Europaea (Olive) Oil Unsaponifiables, Palmitic Acid, Phytosphingosine HCl, Sphingomonas Ferment Extract, Caprooyl Phytosphingosine, Ethyl Linoleate
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