Acetyl Hexapeptide-1
A synthetic peptide. The maker links it to soothing and an even skin tone; data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetyl hexapeptide-1 (INCI: Acetyl Hexapeptide-1) is a synthetic six-amino-acid peptide. The manufacturer links it to a soothing effect and a more even tone, and it appears in serums and creams as a signaling ingredient. The evidence is thin. Signaling peptides are an interesting area, but for this one specifically the public clinical data are limited, so it makes sense to treat it as a supporting active with modest benefit rather than a proven lead ingredient. Topically there is no meaningful systemic exposure, so it can be used during pregnancy and breastfeeding without concern. Tolerance is good: irritation and allergy risk are both low. Synthetic peptides at cosmetic doses rarely cause discomfort, which makes it comfortable even on sensitive skin.
Frequently asked questions
Is Acetyl Hexapeptide-1 safe during pregnancy?
Acetyl Hexapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Hexapeptide-1 for?
Acetyl Hexapeptide-1 suits: normal, dry, combination, oily, sensitive.
What is Acetyl Hexapeptide-1 and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Acetyl Hexapeptide-1?
The INCI name is Acetyl Hexapeptide-1.
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