A synthetic peptide. The maker links it to soothing and an even skin tone; data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; data limited.
Acetyl hexapeptide-1 (INCI: Acetyl Hexapeptide-1) is a synthetic six-amino-acid peptide. The manufacturer links it to a soothing effect and a more even tone, and it appears in serums and creams as a signaling ingredient. The evidence is thin. Signaling peptides are an interesting area, but for this one specifically the public clinical data are limited, so it makes sense to treat it as a supporting active with modest benefit rather than a proven lead ingredient. Topically there is no meaningful systemic exposure, so it can be used during pregnancy and breastfeeding without concern. Tolerance is good: irritation and allergy risk are both low. Synthetic peptides at cosmetic doses rarely cause discomfort, which makes it comfortable even on sensitive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Hexapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Hexapeptide-1 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl Hexapeptide-1. It may also appear as: Ацетилгексапептид-1.
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