A synthetic hexapeptide. The maker links it to an even skin tone; data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; data limited.
Hexapeptide-2 (INCI: Hexapeptide-2) is a synthetic peptide of six amino acids. Manufacturers link it to a more even tone and to pigment modulation, based on its structural similarity to fragments of hormones involved in melanin. On efficacy stay cautious: it is a supporting component with a thin evidence base. Strong independent studies in human skin are limited and most claims come from the supplier. It can accompany a brightening routine but does not replace actives with clear backing such as vitamin C or niacinamide. In pregnancy and breastfeeding topical use poses no meaningful systemic problem. Tolerance is good, with low irritation and allergy potential, sensitive skin included. Reactions are infrequent.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Hexapeptide-2 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Hexapeptide-2 suits: normal, dry, combination, oily, sensitive.
A synthetic hexapeptide.
The INCI name is Hexapeptide-2. It may also appear as: Гексапептид-2.
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