Hexapeptide-2
A synthetic hexapeptide. The maker links it to an even skin tone; data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Hexapeptide-2 (INCI: Hexapeptide-2) is a synthetic peptide of six amino acids. Manufacturers link it to a more even tone and to pigment modulation, based on its structural similarity to fragments of hormones involved in melanin. On efficacy stay cautious: it is a supporting component with a thin evidence base. Strong independent studies in human skin are limited and most claims come from the supplier. It can accompany a brightening routine but does not replace actives with clear backing such as vitamin C or niacinamide. In pregnancy and breastfeeding topical use poses no meaningful systemic problem. Tolerance is good, with low irritation and allergy potential, sensitive skin included. Reactions are infrequent.
Frequently asked questions
Is Hexapeptide-2 safe during pregnancy?
Hexapeptide-2 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Hexapeptide-2 for?
Hexapeptide-2 suits: normal, dry, combination, oily, sensitive.
What is Hexapeptide-2 and what does it do in cosmetics?
A synthetic hexapeptide.
What's the INCI name for Hexapeptide-2?
The INCI name is Hexapeptide-2.
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