A synthetic histidine-derived active. The maker links it to evening skin tone; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A brightening active. Safe; independent data limited.
Glutamylamidoethyl Imidazole is a synthetic active, a derivative related to the amino acid histidine. Its INCI name is Glutamylamidoethyl Imidazole. In a formula it is included in products aimed at evening out skin tone. On efficacy it is worth being plain. The manufacturer links it to a more even tone, but independent data are thin. For now it fits better as a supportive active with a modest evidence base than as a proven fix for pigmentation. Do not expect marked results. Applied topically it has no systemic relevance, so it can be used during pregnancy and breastfeeding. Tolerance is high, with a low irritation and allergy potential, and it suits sensitive skin. Most people see no reaction.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Glutamylamidoethyl Imidazole is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Glutamylamidoethyl Imidazole suits: normal, dry, combination, oily, sensitive.
A synthetic histidine-derived active.
The INCI name is Glutamylamidoethyl Imidazole. It may also appear as: Глутамиламидоэтил имидазол.
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