N-Acetyl Glucosamine
Amino sugar, a precursor of hyaluronic acid. Inhibits tyrosinase, so it lightens post-acne marks and melasma, especially when paired with niacinamide. Also supports skin HA synthesis.
Evidence by route
Topical application
Double-blind RCTs with 2% NAG plus 4% niacinamide reduce visible hyperpigmentation significantly better than placebo over 8–10 weeks. Well tolerated, unlike hydroquinone.
- Bissett DL et al. J Cosmet Dermatol. 2007;6(1):20-26. PMID 17348991
- Kimball AB et al. Br J Dermatol. 2010;162(2):435-441. PMID 19845667
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
N-Acetyl Glucosamine (NAG) is the acetylated form of the amino sugar glucosamine. A natural substrate for hyaluronic acid and dermal proteoglycan synthesis. In cosmetics used as a brightening, moisturizing, and anti-aging ingredient. Mechanism. Suppresses tyrosinase by inhibiting its glycosylation – reduces melanin production (Bissett 2007). Stimulates hyaluronic acid synthesis in fibroblasts – enhances deep skin hydration. Antioxidant effect. Where applied. Serums and creams for hyperpigmentation, melasma, post-acne marks, moisturizing serums, anti-aging products. Concentration 2–10%. Often combined with niacinamide – synergistically suppress melanogenesis (Bissett 2007). In Spain in Sesderma Acglicolic, Mesoestetic Whitening, Endocare C lines. Evidence base. Double-blind RCT Bissett 2007 (n=202) showed 30% melasma and post-inflammatory pigmentation reduction over 8 weeks with 2% NAG + 4% niacinamide. Less effective than hydroquinone 4% but without irritation and contact allergy. Safety. CIR confirmed safety up to 10%. Hypoallergenic, non-comedogenic, non-irritating, does not photosensitize. Pregnancy and lactation – safe. The drug of choice for gestational melasma along with niacinamide, ferulic acid, MAP, and SPF 50+. Unlike hydroquinone, permitted in pregnancy. Who it suits. Sensitive skin, melasma, post-acne pigmentation, photoaging, patients with hydroquinone intolerance. Often combined with vitamin C derivatives, niacinamide, retinol.
Frequently asked questions
Is N-Acetyl Glucosamine safe during pregnancy?
N-Acetyl Glucosamine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is N-Acetyl Glucosamine for?
N-Acetyl Glucosamine suits: normal, dry, oily, combination, sensitive.
What is N-Acetyl Glucosamine and what does it do in cosmetics?
Amino sugar, a precursor of hyaluronic acid.
What's the INCI name for N-Acetyl Glucosamine?
The INCI name is Acetyl Glucosamine. It may also appear as: N-Acetyl Glucosamine, NAG, GlcNAc.
See N-Acetyl Glucosamine in a product composition right on the store page
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