Acetyl Hexapeptide-49
A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetyl Hexapeptide-49 (INCI Acetyl Hexapeptide-49) is a synthetic peptide with a protective acetyl group, used in anti-ageing products. By the maker's design, this short chain of amino acids is meant to send skin cells signals linked to firmness and renewal. It is worth being honest about efficacy. This is a promising but poorly studied signalling ingredient: the main data come from the raw-material supplier, and independent clinical work is sparse. I would call it a supporting ingredient in a formula rather than a proven active. You should not expect miracles from a peptide at cream-level concentration; it is more of a pleasant addition to basic care. During pregnancy and breastfeeding the peptide can be used. The molecule is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Synthetic peptides of this class usually behave calmly even on reactive skin.
Frequently asked questions
Is Acetyl Hexapeptide-49 safe during pregnancy?
Acetyl Hexapeptide-49 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Hexapeptide-49 for?
Acetyl Hexapeptide-49 suits: normal, dry, combination, oily, sensitive.
What is Acetyl Hexapeptide-49 and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Acetyl Hexapeptide-49?
The INCI name is Acetyl Hexapeptide-49.
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