A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Acetyl Hexapeptide-49 (INCI Acetyl Hexapeptide-49) is a synthetic peptide with a protective acetyl group, used in anti-ageing products. By the maker's design, this short chain of amino acids is meant to send skin cells signals linked to firmness and renewal. It is worth being honest about efficacy. This is a promising but poorly studied signalling ingredient: the main data come from the raw-material supplier, and independent clinical work is sparse. I would call it a supporting ingredient in a formula rather than a proven active. You should not expect miracles from a peptide at cream-level concentration; it is more of a pleasant addition to basic care. During pregnancy and breastfeeding the peptide can be used. The molecule is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Synthetic peptides of this class usually behave calmly even on reactive skin.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Hexapeptide-49 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Hexapeptide-49 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl Hexapeptide-49. It may also appear as: Ацетил гексапептид-49.
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