Acetyl Hexapeptide-8 (Argireline)
INCI: Acetyl Hexapeptide-8
Synthetic peptide, a SNAP-25 fragment. Marketed as 'botox in a jar' – suppresses neurotransmitter release at the neuromuscular junction. In reality, the effect is orders of magnitude weaker than botulinum toxin.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Small industry-sponsored studies show 17–30% reduction in expression wrinkle depth over 30 days. No independent placebo-controlled RCTs. Actual penetration through the stratum corneum is the key question for all peptides.
- Blanes-Mira C et al. Int J Cosmet Sci. 2002;24(5):303-310.
Working concentrations
5–10% solution (0.005–0.05% as peptide)
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSkin types
Suitable for
Frequently asked questions
Is Acetyl Hexapeptide-8 (Argireline) safe during pregnancy?
Safety data for Acetyl Hexapeptide-8 (Argireline) during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Acetyl Hexapeptide-8 (Argireline) for?
Acetyl Hexapeptide-8 (Argireline) suits: normal, dry, sensitive, combination, oily.