A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Acetyl sh-Polypeptide-145 Amide (INCI Acetyl sh-Polypeptide-145 Amide) is a biotech peptide: the sh prefix stands for synthetic human, meaning the sequence mirrors a human protein and is made by fermentation. It is added to anti-ageing products as a signalling ingredient for firmness and skin renewal. I view its efficacy calmly and without overstatement. The evidence base is still modest: the main data come from the raw-material developer, with little independent clinical work. This is a supporting ingredient in a formula, not a standalone proven active. It complements a routine but does not deliver the result on its own. During pregnancy and breastfeeding it can be used. The peptide is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Biotech peptides of this kind are usually very skin-friendly.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl sh-Polypeptide-145 Amide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl sh-Polypeptide-145 Amide suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl sh-Polypeptide-145 Amide. It may also appear as: Ацетил sh-полипептид-145 амид.
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