Acetyl sh-Polypeptide-145 Amide
A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetyl sh-Polypeptide-145 Amide (INCI Acetyl sh-Polypeptide-145 Amide) is a biotech peptide: the sh prefix stands for synthetic human, meaning the sequence mirrors a human protein and is made by fermentation. It is added to anti-ageing products as a signalling ingredient for firmness and skin renewal. I view its efficacy calmly and without overstatement. The evidence base is still modest: the main data come from the raw-material developer, with little independent clinical work. This is a supporting ingredient in a formula, not a standalone proven active. It complements a routine but does not deliver the result on its own. During pregnancy and breastfeeding it can be used. The peptide is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Biotech peptides of this kind are usually very skin-friendly.
Frequently asked questions
Is Acetyl sh-Polypeptide-145 Amide safe during pregnancy?
Acetyl sh-Polypeptide-145 Amide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl sh-Polypeptide-145 Amide for?
Acetyl sh-Polypeptide-145 Amide suits: normal, dry, combination, oily, sensitive.
What is Acetyl sh-Polypeptide-145 Amide and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Acetyl sh-Polypeptide-145 Amide?
The INCI name is Acetyl sh-Polypeptide-145 Amide.
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