A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Acetyl Hexapeptide-51 Amide (INCI Acetyl Hexapeptide-51 Amide) is a synthetic peptide with an amide modification, used in anti-ageing formulas. The maker links it to support for firmness and skin renewal, and the amide group is meant to improve the molecule's stability in the product. The approach to efficacy is sober. The evidence base is still modest: most data come from the raw-material developer and independent studies are few. This is a supporting ingredient in a formula, not a standalone proven active. It may contribute to overall care, but expectations should not rest on it alone. During pregnancy and breastfeeding it can be used. When applied topically, the large peptide molecule does not penetrate the skin systemically, and there are no restrictions. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Peptides of this group rarely trigger reactions even on skin prone to sensitivity.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Hexapeptide-51 Amide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Hexapeptide-51 Amide suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl Hexapeptide-51 Amide. It may also appear as: Ацетил гексапептид-51 амид.
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