Acetyl Hexapeptide-51 Amide
A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetyl Hexapeptide-51 Amide (INCI Acetyl Hexapeptide-51 Amide) is a synthetic peptide with an amide modification, used in anti-ageing formulas. The maker links it to support for firmness and skin renewal, and the amide group is meant to improve the molecule's stability in the product. The approach to efficacy is sober. The evidence base is still modest: most data come from the raw-material developer and independent studies are few. This is a supporting ingredient in a formula, not a standalone proven active. It may contribute to overall care, but expectations should not rest on it alone. During pregnancy and breastfeeding it can be used. When applied topically, the large peptide molecule does not penetrate the skin systemically, and there are no restrictions. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Peptides of this group rarely trigger reactions even on skin prone to sensitivity.
Frequently asked questions
Is Acetyl Hexapeptide-51 Amide safe during pregnancy?
Acetyl Hexapeptide-51 Amide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Hexapeptide-51 Amide for?
Acetyl Hexapeptide-51 Amide suits: normal, dry, combination, oily, sensitive.
What is Acetyl Hexapeptide-51 Amide and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Acetyl Hexapeptide-51 Amide?
The INCI name is Acetyl Hexapeptide-51 Amide.
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