Copper Peptides (GHK-Cu)
Tripeptide-copper complex that stimulates synthesis of collagen, elastin, and glycosaminoglycans. Accelerates wound healing and exerts anti-inflammatory effects.
Evidence by route
Topical application
Wound and post-surgical studies show accelerated regeneration. Anti-aging RCTs are limited by small samples and industry sponsorship. In vitro effects are well documented, but more large clinical trials are needed.
- Pickart L et al. Oxid Med Cell Longev. 2012;2012:324832. PMID 22666519
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Working concentrations
- 0.1–1% (as peptide)
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Unknown
- Suitable for
- Normal, Dry, Sensitive, Combination
Combinations with other ingredients
About this ingredient
Copper Peptides GHK-Cu (Copper Tripeptide-1) is the tripeptide glycyl-L-histidyl-L-lysine complexed with copper. Discovered in 1973 in human plasma by Loren Pickart: the blood level at 60 is 6 times lower than at 20. In skin GHK-Cu activates fibroblasts, stimulates collagen, elastin, and glycosaminoglycan synthesis, and accelerates wound regeneration. Mechanism. Copper binding increases the metal's availability to lysyl oxidase and superoxide dismutase. GHK-Cu suppresses pro-inflammatory cytokines (TNF-α, IL-6) and stimulates angiogenesis. At the molecular level it modulates the expression of more than 4000 genes, as shown by Pickart 2018 transcriptomic analysis. Where applied. Anti-aging serums and creams, post-procedure recovery products (after microneedling, laser, chemical peels), scalp formulas (stimulate hair growth). In Spain – The Ordinary Buffet + Copper Peptides 1%, Niod CAIS 3, Mesoestetic AOX Ferulic, Mediderma Glycopeel post-care. Evidence base. Leyden 2002 RCT in 67 women with photoaging: GHK-Cu cream over 12 weeks improved fine lines and skin density vs placebo. Finkley 2005 showed stimulation of collagen synthesis in skin biopsies. In trichology GHK-Cu is part of PRP protocols and topical hair growth treatments. Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Irritation rare. No direct sun photosensitization, but the bright blue-green color of the product (typical of copper) sometimes alarms users. Controversies. Don't combine with vitamin C in the same serum – ascorbic acid reduces copper to ionic form, which destroys the peptide complex. Use them at different times of day (no copper needed in the morning, use in the evening; vitamin C – in the morning). Pregnancy and lactation – insufficient data. The breastfeeding safety profile is indirectly normal; for pregnancy manufacturers recommend caution – it's safer to switch to copper-free peptides during that period. Best suited to: mature skin, post-procedure care, mild and moderate photoaging, barrier recovery support. One of the most evidence-supported peptides in dermatologic cosmetics.
Frequently asked questions
Is Copper Peptides (GHK-Cu) safe during pregnancy?
Safety data for Copper Peptides (GHK-Cu) during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Copper Peptides (GHK-Cu) for?
Copper Peptides (GHK-Cu) suits: normal, dry, sensitive, combination.
What is Copper Peptides (GHK-Cu) and what does it do in cosmetics?
Tripeptide-copper complex that stimulates synthesis of collagen, elastin, and glycosaminoglycans.
What's the INCI name for Copper Peptides (GHK-Cu)?
The INCI name is Copper Tripeptide-1. It may also appear as: GHK-Cu, Copper Peptides.
What concentration of Copper Peptides (GHK-Cu) is effective?
0.1–1% (as peptide)
See Copper Peptides (GHK-Cu) in a product composition right on the store page
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Anti-aging, Soothing, Post-retinoid recovery, Post-procedure recovery
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