sh-Polypeptide-121
A biotech polypeptide (growth factor). The maker links it to skin recovery; independent data are limited. Well tolerated.
Evidence by route
Topical application
A peptide active. Well tolerated; data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
sh-Polypeptide-121 is a biotech-derived polypeptide, part of the growth-factor family produced by fermentation. In skincare formulas it is linked to repair and support of skin renewal. Efficacy calls for caution. Growth factors draw interest for their role in cell signaling, but independent data on this specific ingredient are scarce and largely come from the manufacturer. It is sensible to treat it as a supporting component rather than an active with a proven standalone effect. No overblown claims. Applied topically the peptide barely crosses into general circulation, so its use during pregnancy and breastfeeding is considered fine. Tolerance is good: low irritation potential and low allergy risk, which makes it suitable for sensitive skin. On very reactive skin, a patch test beforehand adds peace of mind.
Frequently asked questions
Is sh-Polypeptide-121 safe during pregnancy?
sh-Polypeptide-121 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is sh-Polypeptide-121 for?
sh-Polypeptide-121 suits: normal, dry, combination, oily, sensitive.
What is sh-Polypeptide-121 and what does it do in cosmetics?
A biotech polypeptide (growth factor).
What's the INCI name for sh-Polypeptide-121?
The INCI name is sh-Polypeptide-121.
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