A biotech polypeptide (growth factor). The maker links it to skin recovery; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A peptide active. Well tolerated; data limited.
sh-Polypeptide-121 is a biotech-derived polypeptide, part of the growth-factor family produced by fermentation. In skincare formulas it is linked to repair and support of skin renewal. Efficacy calls for caution. Growth factors draw interest for their role in cell signaling, but independent data on this specific ingredient are scarce and largely come from the manufacturer. It is sensible to treat it as a supporting component rather than an active with a proven standalone effect. No overblown claims. Applied topically the peptide barely crosses into general circulation, so its use during pregnancy and breastfeeding is considered fine. Tolerance is good: low irritation potential and low allergy risk, which makes it suitable for sensitive skin. On very reactive skin, a patch test beforehand adds peace of mind.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
sh-Polypeptide-121 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
sh-Polypeptide-121 suits: normal, dry, combination, oily, sensitive.
A biotech polypeptide (growth factor).
The INCI name is sh-Polypeptide-121. It may also appear as: sh-Полипептид-121, Биотехнологический полипептид.
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