A recombinant growth factor grown in Nicotiana benthamiana tobacco. The maker links it to skin renewal and firmness; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A biotech growth factor. The maker links it to skin firmness; independent data limited.
sh-Oligopeptide-1 is a biotech peptide that corresponds to epidermal growth factor (EGF). In this version it is produced in the plant Nicotiana benthamiana. INCI: Nicotiana Benthamiana sh-Oligopeptide-1. In skin, EGF takes part in cell division and renewal. In a formula it works as an active component with a claimed regenerating and anti-aging action. Topical growth factors are under active study, early data exist, but the evidence base is still limited, penetration of the large molecule is low, and stimulation of cell division is treated with caution. It is a promising but supporting active with an incomplete base, not a treatment with a proven result. Pregnancy safety. Topical use, no evidence of harm, but growth factors are used with caution during pregnancy. Tolerance. Irritation and allergen potential are low.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Nicotiana Benthamiana sh-Oligopeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Nicotiana Benthamiana sh-Oligopeptide-1 suits: normal, dry, combination, oily, sensitive.
A recombinant growth factor grown in Nicotiana benthamiana tobacco.
The INCI name is Nicotiana Benthamiana sh-Oligopeptide-1. It may also appear as: sh-олигопептид-1, sh-Oligopeptide-1, Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1.
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